Increased endothelin-1 plasma levels in patients with multiple sclerosis

Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
Timo HaufschildJ Flammer

Abstract

We tested the hypothesis that the plasma level of endothelin-1 (ET-1) is increased in patients with multiple sclerosis (MS). The peptide ET-1 is one of the most potent known vasoconstrictors. An increased level of endothelin could explain some of the vascular symptoms of these patients. A specific radioimmunoassay was used to determine ET-1 plasma levels. Twenty patients with MS were compared to 20 age- and sex-pair-matched healthy subjects. The plasma ET-1 levels were, on average, 224% higher in the patients with MS than in the controls (p < 0.005). The mean ET-1 levels (mean +/- standard deviation [SD]) were 3.5 +/- 0.83 pg/mL (min 2.13, max 5.37 pg/mL) in patients with MS and 1.56 +/- 0.3 pg/mL (min 0.9, max 2.13 pg/mL) in healthy volunteers. Neither the different forms nor stages of MS had an influence on the results. The ET-1 level was also not correlated with the duration of the disease. The plasma ET-1 level is markedly and significantly increased in patients with MS. Neither the cause of such an increase nor the pathogenetic role is known.

References

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Citations

Jan 7, 2004·Journal of the Neurological Sciences·Shauna KirkStephen Karlik
Jan 5, 2002·American Journal of Ophthalmology·Mona PacheJosef Flammer
Nov 20, 2003·Journal of Autoimmunity·S L Kirk, S J Karlik
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Dec 6, 2007·Survey of Ophthalmology·Matthias C GrieshaberJosef Flammer
Dec 6, 2007·Survey of Ophthalmology·Josef Flammer, Maneli Mozaffarieh
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