Increased endothelin activity mediates augmented distal nephron acidification induced by dietary protein

Journal of the American Society of Nephrology : JASN
Apurv KhannaDonald E Wesson

Abstract

The hypothesis that increased dietary protein augments distal nephron acidification and does so through an endothelin (ET-1)-dependent mechanism was tested. Munich-Wistar rats that ate minimum electrolyte diets of 50% (HiPro) and 20% (CON) casein-provided protein, the latter comparable to standard diet, were compared. HiPro versus CON had higher distal nephron net HCO(3) reabsorption by in vivo microperfusion (37.8 +/- 3.2 versus 16.6 +/- 1.5 pmol/mm per min; P < 0.001) as a result of higher H(+) secretion (41.3 +/- 4.0 versus 23.0 +/- 2.1 pmol/mm per min; P < 0.002) and lower HCO(3) secretion (-3.5 +/- 0.4 versus -6.4 +/- 0.8 pmol/mm per min; P < 0.001). Perfusion with H(+) inhibitors support that increased H(+) secretion was mediated by augmented Na(+)/H(+) exchange and H(+)-ATPase activity without augmented H(+),K(+)-ATPase activity. HiPro versus CON had higher levels of urine ET-1 excretion, renal cortical ET-1 addition to microdialysate in vivo, and renal cortical ET-1 mRNA, consistent with increased renal ET-1 production. Oral bosentan, an ET A/B receptor antagonist, decreased distal nephron net HCO(3) reabsorption (22.4 +/- 1.9 versus 37.8 +/- 3.2 pmol/mm per min; P < 0.001) as a result of lower H(+) secretion (28.4 +/- ...Continue Reading

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Citations

Dec 16, 2004·The Journal of Clinical Investigation·Stephen L Gluck
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Karin E FinbergRichard P Lifton
Aug 26, 2014·BMC Nephrology·Tanushree BanerjeeNeil R Powe
Oct 22, 2014·Nature Reviews. Nephrology·Nishank Jain, Robert F Reilly
Feb 27, 2013·Advances in Chronic Kidney Disease·Julia J Scialla, Cheryl A M Anderson
Oct 6, 2006·Kidney International·D E Wesson
Oct 31, 2006·Seminars in Nephrology·Donald E Wesson
Jan 18, 2006·Journal of Immunological Methods·A J RosenbloomT L Whiteside
Mar 11, 2015·Current Hypertension Reports·Divya HariharanHolly Kramer
Aug 16, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Casey M RebholzJosef Coresh
Jan 7, 2006·Journal of the American Society of Nephrology : JASN·Donald E WessonSharma Prabhakar
Mar 22, 2014·Journal of the American Society of Nephrology : JASN·Lisa BounoureCarsten A Wagner
May 6, 2005·Journal of the American Society of Nephrology : JASN·Apurv KhannaDonald E Wesson
Apr 17, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Manije Darooghegi MofradLeila Azadbakht
Nov 16, 2019·Advances in Nutrition·Holly Kramer
Nov 15, 2019·Current Opinion in Nephrology and Hypertension·Nimrit Goraya, Donald E Wesson
Sep 29, 2020·American Journal of Physiology. Renal Physiology·Dominique M BoveeEwout J Hoorn
Aug 4, 2012·American Journal of Physiology. Renal Physiology·Alexandra PalliniReto Krapf
May 22, 2009·American Journal of Physiology. Renal Physiology·Stephanie M Busque, Carsten A Wagner
Jan 29, 2020·Journal of the American Society of Nephrology : JASN·Donald E WessonDavid A Bushinsky
May 13, 2018·Nutrients·Nimrit Goraya, Donald E Wesson
Nov 10, 2020·American Journal of Physiology. Renal Physiology·Elinor C Mannon, Paul M O'Connor
Mar 21, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Donald E Wesson
May 20, 2021·Current Opinion in Nephrology and Hypertension·Sebastian HultinSunil V Badve

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