Increased eosinophil cationic protein levels in bronchoalveolar lavage from wheezy infants

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
I AzevedoP Scheinmann

Abstract

Although studies examining the serum suggest a role for eosinophils in wheezing episodes in infants and toddlers, the presence of a chronic eosinophilic inflammation within their airways remains to be demonstrated. In this study we investigated whether eosinophil cationic protein (ECP) levels are increased in BAL fluid (BALF) from infants and toddlers with recurrent wheezing episodes, during an asymptomatic period. The levels of ECP in BALF were quantitated by radioimmunoassay in 61 children (36 with severe recurrent episodes of wheezing and 25 who were non-wheezy), aged 6-36 months, in whom flexible bronchoscopy was clinically indicated. BALF eosinophil counts were < or = 1% in all patients and did not differ in wheezers, compared to non-wheezers. In contrast, ECP levels in BALF were > or = 2.2 micrograms/l in 18 of 36 (50%) wheezy infants but in only three of 25 (12%) control infants (p < 0.01). Neutrophil counts were significantly higher in the wheezer group than in the non-wheezer group (8.1 x 10(3) cells/ml vs. 3.0 x 10(3) cells/ml). ECP levels in the BALF were not correlated with the absolute number of eosinophils (r = 0.03; p = 0.8) but were correlated with the absolute number of neutrophils (r = 0.54; p = 0.001). There ...Continue Reading

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Citations

Apr 3, 2004·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Yumi YamadaOsamu Arisaka
Dec 21, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Christophe MarguetBertrand Macé
Oct 28, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Sufian GhdifanChristophe Marguet
Sep 13, 2002·Chest·Muriel Le BourgeoisJacques de Blic
Aug 12, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ahmed A Arif
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Javier MonteseirínJosé Conde

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