Increased EpCAM expression in malignant insulinoma: potential clinical implications

European Journal of Endocrinology
Andreas RaffelNikolas H Stoecklein

Abstract

EpCAM (CD326) is overexpressed in progenitor cells of endocrine pancreatic islands of Langerhans during fetal development and was suggested to act as a morphoregulatory molecule in pancreatic island ontogeny. We tested whether EpCAM overexpression is reactivated in insulinomas, endocrine tumors arising in the pancreas. We used monoclonal anti-EpCAM antibody Ber-Ep4 for immunohistochemistry on formalin-fixed and paraffin-embedded tumor material. We analyzed 53 insulinomas: 40 benign (disease stage<IIa) and 13 malignant tumors (disease stage IIIb/IV). Disease stage disposition followed new TNM classification of the European Neuroendocrine Tumor Society (ENETS) for foregut neuroendocrine tumors (2006). Additionally, ten insulinoma metastases were analyzed. Clinical follow-up was available for overall survival analysis from 49 patients. The EpCAM expression of the islands of Langerhans was classified as 2+ in healthy pancreatic tissue. In 38% of the benign insulinomas (disease stage<IIa), we found strong (3+) EpCAM expression. In contrast, malignant insulinomas (disease stage IIIb/IV) and their metastases exhibited a strong (3+) EpCAM expression with 78 and 80% respectively, significantly more frequent (P<0.01). The malignant tissu...Continue Reading

Citations

Jul 9, 2013·BMC Research Notes·Feride KroepilNikolas H Stoecklein
Jul 7, 2012·Surgery·Alexander RehdersWolfram Trudo Knoefel
May 12, 2012·Environmental and Molecular Mutagenesis·Qingying LuoZunzhen Zhang
Sep 19, 2012·Genes, Chromosomes & Cancer·Stefan SchönbergerArndt Borkhardt
Dec 19, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mohid S KhanTim Meyer
Oct 13, 2012·The American Journal of Surgical Pathology·Sameer DhayatNikolas Hendrik Stoecklein
Aug 2, 2019·The Journal of Clinical Endocrinology and Metabolism·Mikkel AndreassenUlrich Knigge
Dec 7, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Mark A Lewis, James C Yao
Sep 11, 2018·World Journal of Gastroenterology : WJG·Michael GockMichael Linnebacher
Apr 1, 2017·Journal of Genetics·Samira SadeghiHossein Tabatabaeian
Jan 13, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mohid S KhanTim Meyer
Nov 1, 2020·The Journal of Biological Chemistry·Nathan RobertsonRyan Cawood
Jan 18, 2021·The Journal of Biological Chemistry·Nathan RobertsonRyan Cawood

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