Increased epidermal growth factor receptor expression at the invasive margin is a negative prognostic factor in colorectal cancer

International Journal of Cancer. Journal International Du Cancer
Ingrid LjuslinderRichard Palmqvist

Abstract

The receptor tyrosine kinase epidermal growth factor receptor (EGFR) is often expressed in solid malignant tumours, and the expression has been correlated to disease progression. Multiple new agents targeted against the EGFR have been developed during the last decade, but treatment selecting criteria are still not clear. This immunohistochemical study includes 386 colorectal cancer patients and focuses on EGFR expression variations within the tumour, comparing central parts to the invasive margin. Positive immunostaining for EGFR was evident in the central part in 176/386 (46%) of analyzed primary tumours. The invasive margin was positive in 222/386 (58%). A similar expression in both the central part and the invasive front was evident in 286/386 (74%). An increased score at the invasive margin compared to central parts (EGFR(i) ) was evident in 97/386 (25%) of the tumours. Moreover, the results show a significant survival disadvantage for the EGFR(i) group, both in potentially curatively resected colon cancer patients (n = 170, p = 0.01) and in potentially curatively resected colon and rectal cancer patients combined (n = 273, p = 0.013). Multivariate survival analysis adjusted for age, gender, bowel localisation, grade, stage...Continue Reading

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Oct 12, 2012·Cellular Oncology (Dordrecht)·Cristina García-InclánMario A Hermsen
Nov 20, 2013·Virchows Archiv : an International Journal of Pathology·Wei-Ren Luo, Kai-Tai Yao
Jan 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Maria L WikbergRichard Palmqvist
Jun 18, 2014·Nature Reviews. Clinical Oncology·José Luis LlorenteMario A Hermsen
Nov 1, 2011·International Journal of Cancer. Journal International Du Cancer·Teppei MorikawaShuji Ogino
May 20, 2019·Journal of Cellular Biochemistry·Xiaolong LiangZheng Xiang

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