Increased epigenetic age in normal breast tissue from luminal breast cancer patients

Clinical Epigenetics
Erin W HofstatterLajos Pusztai

Abstract

Age is one of the most important risk factors for developing breast cancer. However, age-related changes in normal breast tissue that potentially lead to breast cancer are incompletely understood. Quantifying tissue-level DNA methylation can contribute to understanding these processes. We hypothesized that occurrence of breast cancer should be associated with an acceleration of epigenetic aging in normal breast tissue. Ninety-six normal breast tissue samples were obtained from 88 subjects (breast cancer = 35 subjects/40 samples, unaffected = 53 subjects/53 samples). Normal tissue samples from breast cancer patients were obtained from distant non-tumor sites of primary mastectomy specimens, while samples from unaffected women were obtained from the Komen Tissue Bank (n = 25) and from non-cancer-related breast surgery specimens (n = 28). Patients were further stratified into four cohorts: age < 50 years with and without breast cancer and age ≥ 50 with and without breast cancer. The Illumina HumanMethylation450k BeadChip microarray was used to generate methylation profiles from extracted DNA samples. Data was analyzed using the "Epigenetic Clock," a published biomarker of aging based on a defined set of 353 CpGs in the human genom...Continue Reading

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Citations

Oct 15, 2019·Journal of Cellular Physiology·Xiaoran MaChanggang Sun
Apr 12, 2020·Experimental Biology and Medicine·Kenneth Raj, Steve Horvath
May 28, 2020·Frontiers in Aging Neuroscience·Monica A WagnerYvette P Conley
Sep 25, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Maeve KielyXiaohong R Yang
Jan 5, 2021·International Journal of Cancer. Journal International Du Cancer·Chung-Ho E Lau, Oliver Robinson
Nov 2, 2020·BMC Cancer·Kaoutar Ennour-IdrissiCaroline Diorio
Sep 17, 2020·Journal of Geriatric Oncology·Jaidyn MuhandiramgeJohn Zalcberg
Feb 26, 2021·Aging·Priscila ChiavelliniRodolfo G Goya
Dec 15, 2020·Seminars in Cell & Developmental Biology·Amita G GhadgeWendy V Ingman
May 24, 2021·Breast Cancer Research : BCR·Shoghag PanjarianJean-Pierre J Issa
Mar 28, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mary E SehlPatricia A Ganz
Jun 18, 2021·NPJ Precision Oncology·Katrina CristallChristopher R Mueller

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Software Mentioned

DNAmAge
STATA

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