Increased error-related brain activity distinguishes generalized anxiety disorder with and without comorbid major depressive disorder.

Journal of Abnormal Psychology
Anna WeinbergGreg Hajcak

Abstract

Generalized anxiety disorder (GAD) and major depressive disorder (MDD) are so frequently comorbid that some have suggested that the 2 should be collapsed into a single overarching "distress" disorder. Yet there is also increasing evidence that the 2 categories are not redundant. Neurobehavioral markers that differentiate GAD and MDD would be helpful in ongoing efforts to refine classification schemes based on neurobiological measures. The error-related negativity (ERN) may be one such marker. The ERN is an event-related potential component presenting as a negative deflection approximately 50 ms following an erroneous response and reflects activity of the anterior cingulate cortex. There is evidence for an enhanced ERN in individuals with GAD, but the literature in MDD is mixed. The present study measured the ERN in 26 GAD, 23 comorbid GAD and MDD, and 36 control participants, all of whom were female and medication-free. Consistent with previous research, the GAD group was characterized by a larger ERN and an increased difference between error and correct trials than controls. No such enhancement was evident in the comorbid group, suggesting comorbid depression may moderate the relationship between the ERN and anxiety. The prese...Continue Reading

References

Aug 1, 1991·Journal of Abnormal Psychology·L A Clark, D Watson
Aug 1, 1988·Journal of Abnormal Psychology·D WatsonG Carey
Apr 1, 1983·Electroencephalography and Clinical Neurophysiology·G GrattonE Donchin
Nov 1, 1993·Psychological Medicine·P Snaith
Mar 1, 1993·Behaviour Research and Therapy·T D BorkovecL Deihl
Sep 8, 1995·Psychiatry Research·N BreslauE Peterson
Feb 15, 1996·Biological Psychiatry·J F ThayerT D Borkovec
Jun 5, 1996·Journal of Affective Disorders·M FavaJ F Rosenbaum
Mar 13, 1998·Annual Review of Psychology·S MinekaL A Clark
Dec 23, 1998·Biological Psychiatry·P J LangB N Cuthbert
May 14, 1999·Current Opinion in Neurobiology·R J DavidsonK Putnam
Mar 31, 2000·Comprehensive Psychiatry·M FavaJ F Rosenbaum
Apr 19, 2000·Nature Neuroscience·J D CohenC S Carter
Mar 7, 2001·Psychological Science·W J GehringL G Nisenson
Dec 12, 2001·Psychiatry Research·S JohannesD E Dietrich
Jan 16, 2003·Physiology & Behavior·Vincent van Veen, Cameron S Carter
Nov 7, 2003·Biological Psychology·Greg HajcakRobert F Simons
Jul 21, 2004·Current Psychiatry Reports·John M Kuzma, Donald W Black
Oct 16, 2004·Psychological Review·Nick YeungJonathan D Cohen
Oct 16, 2004·Science·K Richard RidderinkhofSander Nieuwenhuis
Nov 3, 2004·Brain and Cognition·Greg HajcakRobert F Simons
Jan 27, 2005·Neuroreport·K Luan PhanGregory J Moore
Feb 22, 2005·Psychophysiology·Bruce D BartholowGabriele Gratton
Mar 25, 2005·Psychophysiology·Greg HajcakRobert F Simons
May 11, 2005·Journal of Psychiatric Research·Martin RuchsowMarkus Kiefer
Jun 10, 2005·Psychophysiology·Jason S MoserRobert F Simons
Jul 6, 2005·NeuroImage·Hugo D CritchleyRaymond J Dolan
Nov 18, 2005·Biological Psychology·Martin RuchsowMarkus Kiefer
Dec 15, 2005·Journal of Abnormal Psychology·David Watson
Dec 15, 2005·Journal of Abnormal Psychology·Jonathan RottenbergIan H Gotlib
May 2, 2006·The American Journal of Psychiatry·John M HettemaKenneth S Kendler
Jun 21, 2006·Brain Research·Maarten A S BoksemMonicque M Lorist
Feb 28, 2007·Journal of Abnormal Psychology·Stewart A ShankmanGerard E Bruder
Apr 4, 2007·The American Journal of Psychiatry·Pearl H Chiu, Patricia J Deldin
May 2, 2007·Psychological Science·Jason R HallChristopher J Patrick
Jun 16, 2007·Neuroscience and Biobehavioral Reviews·Christopher G DaveyNicholas B Allen
Aug 11, 2007·Behavioural Brain Research·Boris SuchanIrene Daum

❮ Previous
Next ❯

Citations

May 24, 2013·Journal of Abnormal Child Psychology·Alexandria MeyerDaniel N Klein
Sep 6, 2013·Biological Psychology·Michael J LarsonScott A Baldwin
Jun 21, 2014·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Michael J LarsonAnn Clawson
Jan 29, 2014·Cognitive, Affective & Behavioral Neuroscience·Julia KlawohnTanja Endrass
Mar 29, 2014·European Archives of Psychiatry and Clinical Neuroscience·Anja RieselTanja Endrass
Apr 22, 2014·Neuroscience and Biobehavioral Reviews·Tanja Endrass, Markus Ullsperger
Jun 26, 2013·Cognitive, Affective & Behavioral Neuroscience·Hans S SchroderJason S Moser
Feb 16, 2016·Psychophysiology·Cecile D Ladouceur
Jan 28, 2016·Psychopharmacology·Kira BaileyBruce D Bartholow
Feb 5, 2013·Biological Psychiatry·Reshmi MarheIngmar H A Franken
Dec 8, 2015·Biological Psychology·Anna WeinbergStewart A Shankman
Feb 7, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Arielle R Baskin-Sommers, Dan Foti
Mar 10, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Anna WeinbergAnja Riesel
Mar 10, 2016·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Alexandria MeyerBrandon E Gibb
Oct 21, 2015·Psychiatry Research·Diane SwickU Turken
Mar 22, 2014·Psychophysiology·Alexandria MeyerGreg Hajcak Proudfit
Jun 13, 2015·Cognitive, Affective & Behavioral Neuroscience·Brady D NelsonGreg Hajcak
May 15, 2015·Cognitive, Affective & Behavioral Neuroscience·Tyson V BarkerNathan A Fox
May 7, 2015·Depression and Anxiety·Douglas S MenninRichard G Heimberg
Jun 14, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Jutta StahlHenning Gibbons
Jan 9, 2016·Hippocampus·Jiook ChaLilianne R Mujica-Parodi
May 27, 2014·Journal of Affective Disorders·Stephanie M GorkaStewart A Shankman
Jul 25, 2013·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Jennifer N BressGreg Hajcak
Feb 11, 2015·Biological Psychiatry·Rosa GrützmannNorbert Kathmann
Jul 6, 2016·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Tim P MoranJason S Moser
Aug 9, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Autumn KujawaK Luan Phan
Jan 2, 2013·International Journal of Offender Therapy and Comparative Criminology·Joshua S May, Kevin M Beaver
Mar 28, 2017·Psychological Medicine·C M GillanT W Robbins
Feb 22, 2017·Scientific Reports·Margherita MalanchiniYulia Kovas
Apr 18, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Alexandria MeyerRoman Kotov
Jul 6, 2018·Human Brain Mapping·Ivan Zubarev, Lauri Parkkonen

❮ Previous
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