Increased estrogen receptor and epidermal growth factor receptor gene product co-expression in surgically resected gastric adenocarcinomas

Journal of Surgical Oncology
G J KoulliasB C Golematis

Abstract

Evidence exists that estrogens influence the action of epidermal growth factor (EGF) and its receptor (EGF-R) at multiple levels. Estrogen and antiestrogen action on gastric and other gastrointestinal malignancies has been evaluated by several groups with conflicting results, and EGF-R has been implicated in the current growth factor-mediated models for gastric cancer progression. ERs and EGF-Rs were detected immunohistochemically in a total of 53 advanced gastric carcinomas using monoclonal antibodies (mAbs) to human ERs and EGF-Rs. ERs were expressed in 30 (56%) and EGF-Rs in 20 (38%) of the gastric tumors. ER(+) gastric tumors were closely associated with the intestinal type (P < 0.01), whereas EGF-R(+) tumors were significantly correlated with poor differentiation status and ER(+) expression (P < 0.01). Of EGF-R(+) tumors, 85% were also ER(+). EGF-R and ER co-expression was demonstrated in 17 tumors (32% of the group). These cases were significantly corelated with poor differentiation and large tumor size upon resection (P < 0.05). ER and EGF-R co-expression indicates that a functional interaction between estrogens and EGF may exist in gastric cancer and that when such an interaction becomes operative, it may lead to dediff...Continue Reading

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Citations

Aug 1, 2004·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Hong Suk SongKun Young Kwon
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Takuo TakehanaAkishi Ooi
Jul 15, 2004·The American Journal of Surgical Pathology·Melinda F Lerwill
Jun 25, 2003·Expert Review of Anticancer Therapy·Mazen Y KhalilDong M Shin
Nov 19, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Russell VangBrigitte M Ronnett
Apr 10, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Armando Gamboa-DominguezBirgit Luber
Dec 6, 2003·The Oncologist·Gordana Vlahovic, Jeffrey Crawford
Aug 4, 2007·The Oncologist·Cesare GridelliFortunato Ciardiello
Jul 1, 2010·Experimental and Therapeutic Medicine·Chiara CarlomagnoSabino DE Placido
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mikiko HayashiKenichi Sugihara
Dec 1, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·V K JaspersK Quakernack
Aug 24, 1999·Pharmacology & Therapeutics·J R Woodburn

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