Increased estrogen receptor beta expression correlates with decreased spine formation in the rat hippocampus

Hippocampus
Sylwia SzymczakLeszek Kaczmarek

Abstract

Estrogens play an important role in the brain function acting through two receptor types, ERalpha and ERbeta, both well-recognized as transcription factors. In this study, we investigated the ERbeta mRNA and protein levels in the rat hippocampus by using two in vivo models that are known to affect synapse formation. Natural estrous-proestrous cycle was used as a model in which a marked decrease in the density of hippocampal synapses was previously observed between proestrus and estrus. We have found that ERbeta mRNA and protein were displayed in high levels in the estrus and in low levels in the proestrous phase. By applying kainic acid (KA) to adult rats, we demonstrated that up-regulation of ERbeta mRNA and protein in hippocampal CA regions was vulnerable to KA-induced excitotoxicity. Furthermore, we note a concomitant decrease of ERbeta in the excitotoxicity-resistant denate gyrus that undergoes intense plastic changes, including synaptogenesis. These data suggested that decreases in ERbeta expression correlated with increase in synapse formation. This notion has been tested in vitro in hippocampal cultures, in which overexpression of ERbeta by means of gene transfection resulted in the lowering of the dendritic spine densit...Continue Reading

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Citations

Feb 1, 2012·Behavioral Neuroscience·Bruce S McEwenElizabeth M Waters
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xin-jie TanJan-Åke Gustafsson
Jul 17, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Satoru SakumaTsunekazu Yamano
Jun 4, 2013·Journal of Neurosurgery·Saleh Zahedi AslShahla Nourizade
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Xiaotang FanJan-Ake Gustafsson
Jun 7, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Rosário MonteiroIsabel Azevedo
Dec 15, 2007·Frontiers in Neuroendocrinology·Joanna L SpencerBruce S McEwen
Oct 6, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Luciano Mendoza-GarcésMarco Cerbón
Mar 15, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Alessandra ColciagoFabio Celotti
Jan 10, 2018·Frontiers in Aging Neuroscience·Sandra ZárateRicardo Gredilla
Nov 21, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Manja SchubertDoris Albrecht
Feb 11, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Linda A BeanThomas C Foster

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