Increased expired NO and roles of CO2 and endogenous NO after venous gas embolism in rabbits.

European Journal of Applied Physiology
P AgvaldD Linnarsson

Abstract

Venous gas embolism (VGE) is a feared complication in diving, aviation, surgery and trauma. We hypothesized that air emboli in the lung circulation might change expired nitric oxide (FeNO). A single intravenous infusion of air was given (100 mul kg(-1)) to three groups of anaesthetized mechanically ventilated rabbits: (A) one with intact NO production, (B) one with intact NO production and where end-tidal CO(2) was controlled, and (C) one with endogenous NO synthesis blockade (L: -NAME, 30 mg kg(-1)). Air infusions resulted in increased FeNO of the control group from 20 (4) [mean (SD)] ppb to a peak value of 39 (4) ppb within 5 min (P < 0.05), and FeNO was still significantly elevated [27 (2) ppb] after 20 min (P < 0.05). Parallel to the NO increase there were significant decreases in end-tidal CO(2 )(ETCO(2)) and mean arterial pressure and an increase in insufflation pressure. In group B, when CO(2) was supplemented after air infusion, NO was suppressed (P = 0.033), but was still significantly elevated compared with pre-infusion control (P < 0.05). In group C, all animals died within 40 min of air infusion whereas all animals in the other groups were still alive at this time point. We conclude that venous air embolization incr...Continue Reading

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Citations

Oct 16, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Pierre RuestNathalie Bureau
May 16, 2009·Respiratory Physiology & Neurobiology·Lars L KarlssonDag Linnarsson
Sep 2, 2010·Nitric Oxide : Biology and Chemistry·Carlos A Dias-JuniorJose E Tanus-Santos
Jan 30, 2019·Pharmacology Research & Perspectives·Kristofer F Nilsson, Lars E Gustafsson
Mar 18, 2020·Pulmonary Circulation·Mads Dam LyhneAsger Andersen

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