Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity.

Inflammatory Bowel Diseases
Shih-Kuang S HongKeith T Wilson

Abstract

Polyamines are important in cell growth and wound repair, but have also been implicated in inflammation-induced carcinogenesis. Polyamine metabolism includes back-conversion of spermine to spermidine by the enzyme spermine oxidase (SMO), which produces hydrogen peroxide that causes oxidative stress. In ulcerative colitis (UC), levels of spermine are decreased compared to spermidine. Therefore, we sought to determine if SMO is involved in UC. Colon biopsies and clinical information from subjects undergoing colonoscopy for evaluation of UC or colorectal cancer screening were utilized from 16 normal controls and 53 UC cases. Histopathologic disease severity was graded and the Mayo Disease Activity Index (DAI) and endoscopy subscore assessed. SMO mRNA expression was measured in frozen biopsies by TaqMan-based real-time polymerase chain reaction (PCR). Formalin-fixed tissues were used for SMO immunohistochemistry. There was a 3.1-fold upregulation of SMO mRNA levels in UC patients compared to controls (P = 0.044), and a 3.7-fold increase in involved left colon versus paired uninvolved right colon (P < 0.001). With worsening histologic injury in UC there was a progressive increase in SMO staining of mononuclear inflammatory cells. Th...Continue Reading

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Citations

Feb 26, 2013·Expert Reviews in Molecular Medicine·Shannon L NowotarskiRobert A Casero
Nov 15, 2013·Chemical Research in Toxicology·Anthony E Pegg
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Andrew C GoodwinRobert A Casero
Oct 12, 2010·Digestive Diseases and Sciences·Toru ShizumaNaoto Fukuyama
Jul 7, 2015·European Journal of Pharmacology·Ailín C RogersAlan W Baird
Jul 15, 2015·Journal of Molecular Biology·Leonor Miller-FlemingMarkus Ralser
Aug 16, 2011·Gastroenterology·Rupesh ChaturvediKeith T Wilson
Mar 14, 2018·Medical Sciences : Open Access Journal·T J Thomas, Thresia Thomas
Jun 21, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tingting HuLing Dong
Oct 20, 2018·The Journal of Biological Chemistry·Tracy Murray StewartRobert A Casero
Jun 5, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Lidan SunChunyu Cao
Aug 23, 2020·Diagnostics·Małgorzata Krzystek-KorpackaKatarzyna Neubauer
Oct 12, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alain P GobertKeith T Wilson
Sep 6, 2018·Nature Reviews. Cancer·Robert A CaseroAnthony E Pegg

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