PMID: 7513552May 1, 1994Paper

Increased expression in vivo of VCAM-1 and E-selectin by the aortic endothelium of normolipemic and hyperlipemic diabetic rabbits

Arteriosclerosis and Thrombosis : a Journal of Vascular Biology
M RichardsonM I Cybulsky

Abstract

Atherosclerosis is enhanced in humans with diabetes mellitus, but the mechanism(s) involved remains unclear. Increased leukocyte-endothelium interaction may be involved, since mononuclear leukocyte adherence to the endothelium is an early event in both experimental atherosclerosis and alloxan-induced diabetes in rabbits. In situ immunohistochemistry was used in en face Häutchen endothelial preparations to identify endothelial cells that stained with antibodies to endothelial leukocyte adhesion molecules (vascular cell adhesion molecule-1 [VCAM-1] and E-selectin), and the number of stained cells per 10,000 cells was determined. Preparations from aortas of diabetic normolipemic and egg yolk diet-induced hyperlipemic diabetic rabbits were compared with those from normoglycemic animals on similar diets. Cross sections of the vessel wall were stained with oil red O and antibodies to VCAM-1, E-selectin, and RAM-11-positive macrophages. After 4 weeks of hyperlipemia the frequency of cells expressing VCAM-1 or E-selectin was significantly increased compared with normolipemic controls; this frequency was further increased in the aortas of hyperlipemic diabetic rabbits. VCAM-1 and E-selectin expression was more frequent in normolipemic d...Continue Reading

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Citations

Jun 1, 1995·Atherosclerosis·R A MalinauskasG A Truskey
Jul 25, 1998·Atherosclerosis·M RichardsonJ C Russell
Sep 17, 1999·Atherosclerosis·F Pérez-JiménezJ M Ordovás
Nov 22, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A P Simopoulos
Aug 2, 2003·Cytokine·Nilima Raina, Khursheed N Jeejeebhoy
Sep 27, 2013·Journal of Medicinal Food·Kuan-Hung LinPi-Yu Chao
Jun 17, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Klaus LeyCatherine C Hedrick
Mar 19, 2016·Canadian Journal of Physiology and Pharmacology·Yu-Ting LinMing-Fen Lee
Nov 6, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Mingdi LiLan Lin
Feb 24, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M NasiekW Foltyn
Mar 12, 1998·Journal of Cardiopulmonary Rehabilitation·S CharoJ A Vita
Feb 13, 2001·Endocrine Reviews·J Calles-Escandon, M Cipolla
Aug 24, 2002·Pediatric Research·Emmanuel KavazarakisThemistocles Karpathios
Apr 18, 2000·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·M SandigK A Rogers
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·W J Zhang, B Frei
Jul 31, 2003·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kazuko Motohashi, Shingo Yamane
Oct 1, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tanja KeiperTriantafyllos Chavakis
Mar 30, 1999·Current Opinion in Lipidology·J D Medh
Jun 13, 2002·American Journal of Physiology. Renal Physiology·Mark S SegalMehmet Koç

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