Increased expression level of corticotropin-releasing hormone in the amygdala and in the hypothalamus in rats exposed to chronic unpredictable mild stress.

Neuroscience Bulletin
Shan-Shan WangJiang-Ning Zhou

Abstract

Corticotropin-releasing hormone (CRH) plays an important role in neuroendocrine, autonomic and behavioral responses to stressors. In the present study, the effect of chronic unpredictable mild stress (CUMS) on CRH neurons was investigated in rat brain. The rats were exposed to one of the stressors each day for 21 d. Immunostaining was performed to detect the CRH-positive neurons in the paraventricular nucleus (PVN) of the hypothalamus and in amygdala. After the stress protocol, the animals showed a reduction in body weight gain as well as reduced sucrose preference and locomotor activity. Interestingly, the CRH neurons in both PVN and central nucleus of the amygdala (CeA) were stimulated by CUMS. The densities of CRH-containing neurons in both PVN and CeA were significantly higher than those in control group. The CRH systems in PVN and CeA may both contribute to depression-like behaviors during CUMS.

References

Jan 1, 1992·Neuroscience and Biobehavioral Reviews·P WillnerM Papp
Jan 1, 1992·Annual Review of Neuroscience·M Davis
Apr 1, 1991·Trends in Pharmacological Sciences·P Willner
Dec 29, 1995·Annals of the New York Academy of Sciences·C A Stratakis, G P Chrousos
Jan 1, 1996·Critical Reviews in Neurobiology·T S Gray, E W Bingaman
Jan 7, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M DavisY Lee
May 27, 1999·Molecular and Chemical Neuropathology·K A Skau, C G Triplett
Oct 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Benno RoozendaalTallie Z Baram
Mar 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Li-Min WuJiang-Ning Zhou
Apr 28, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P C Casarotto, R Andreatini
Oct 5, 2007·Nature Clinical Practice. Neurology·Diego CentonzeGiacomo Koch

❮ Previous
Next ❯

Citations

Jul 2, 2011·Behavioural Brain Research·Amy R FurayJohn F Neumaier
Oct 15, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Henry R KranzlerJoel Gelernter
Jul 11, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jin-Fang GeFei-Hu Chen
Oct 18, 2011·Experimental Neurology·Ann M HemmerleKim B Seroogy
Jul 11, 2012·Stress : the International Journal on the Biology of Stress·N ZeeniC Chaumontet
Jun 16, 2015·Brain Research·Yu-Mian ShuJiang-Ning Zhou
Jan 2, 2015·The International Journal of Neuropsychopharmacology·Cong-Cong QiJiang-Ning Zhou
Jul 11, 2012·Neuroscience and Biobehavioral Reviews·Matthew N HillJoanne Weinberg
Jul 31, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Anjana Bali, Amteshwar Singh Jaggi
Jul 17, 2013·Journal of Affective Disorders·Jesper KroghMerete Nordentoft
Aug 15, 2020·Circulation. Cardiovascular Imaging·Michael T OsborneAhmed Tawakol
Jul 15, 2017·Scientific Reports·Jamshid FarajiGerlinde A S Metz
Apr 28, 2019·Current Treatment Options in Cardiovascular Medicine·Tawseef DarMichael T Osborne
Dec 29, 2020·Frontiers in Neuroscience·Catherine GebhardMichael Fiechter
May 1, 2021·Journal of Personalized Medicine·Flavia DiggelmannMichael Fiechter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.