PMID: 7540252Jan 1, 1995Paper

Increased expression of adhesion molecules (CD54, CD29 and CD44) on fibroblasts infected with cytomegalovirus

Microbiology and Immunology
M ItoM Sakurai

Abstract

The expression of ICAM-1 (CD54), beta 1 integrin (CD29), and CD44 on cytomegalovirus (CMV)-infected human embryonic fibroblasts (HEF) was analyzed by flow cytometry. The expression of these adhesion molecules increased significantly on CMV-infected HEF, on days 2 and 5 after inoculation, compared to uninfected HEF. However, the expression of these adhesion molecules decreased on herpes simplex virus (HSV)-1 and varicella-zoster virus (VZV)-infected HEF. Increased expression was not observed on HEF treated either with inactivated CMV or with supernatant fluid of CMV-infected cells. The addition of anti-cytokine (TNF-alpha, IL-1 beta, or IFN-gamma) antibodies had no effect on the increase of these adhesion molecules. This suggests that the increase in CD54, CD29, and CD44 on CMV-infected cells requires active virus replication and was not mediated by a soluble factor released from CMV-infected cells. Changes in adhesion molecules on CMV-infected fibroblasts may contribute to inflammation induced by CMV infection.

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Citations

Oct 18, 2007·Journal of Gastroenterology·Akifumi KuwabaraKatsuyoshi Hatakeyama
Jan 1, 1996·Microbiology and Immunology·M WatanabeM Sakurai
Oct 1, 1996·Oral Microbiology and Immunology·B Parra, J Slots
Jan 1, 1997·The British Journal of Ophthalmology·S N ZhuG Duncker
Feb 11, 2015·The Journal of Gene Medicine·Timothy M MartinAngela K Pannier
Jun 15, 1999·Journal of Periodontology·A ContrerasJ Slots
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gary ChanAndrew D Yurochko
Oct 23, 2020·Immunological Reviews·Hannah KaminskiLionel Couzi

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