Increased expression of amyloid precursor protein in oral squamous cell carcinoma

International Journal of Cancer. Journal International Du Cancer
Shun-Yao KoTsung-Yun Liu

Abstract

In our previous study, we identified amyloid precursor protein (APP) in an oral squamous cell carcinoma (OSCC)-enriching subtractive hybridization library. Our present study attempts to define the significance of APP expression in the genesis of OSCC. RT-PCR analysis showed increase in APP mRNA expression for more than 2-fold in 76% of OSCC (n = 55) relative to corresponding non-cancerous matched tissues (NCMT). The majority of esophageal SCCs also had increase in APP mRNA expression. OSCC patients exhibiting increase in APP mRNA expression had significantly lower survival rate compared to patients exhibiting the opposite status. Western blotting analysis identified APP751 and APP770 as the major APP isoforms in oral keratinocytes. A high correlation between mRNA and protein expressions of APP was noted in OSCC/NCMT pairs. Immunohistochemistry further showed a remarkable increase of APP in OSCC tissue relative to NCMT. Treatment with an antisense oligonucleotide against APP reduced cellular and secreted APP as well as growth in an OSCC cell line. Our study provides novel clues that APP expression is involved in the proliferation and carcinogenesis of OSCC. Correlated with such pathogenesis was the survival of its victims. The d...Continue Reading

References

Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D J SelkoeT Oltersdorf
Jan 1, 1994·Annual Review of Neuroscience·D J Selkoe
Nov 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y C KoC C Tsai
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·C U PietrzikV Herzog
Mar 26, 2002·Journal of Toxicology and Environmental Health. Part a·Chiu-Lan ChenTsung-Yun Liu
Apr 6, 2002·Histochemistry and Cell Biology·A SchmitzV Herzog
Oct 11, 2002·The Journal of Pathology·Shu-Chun LinKuo-Wei Chang
Jul 9, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shun-Yao KoTsung-Yun Liu
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas QuastVolker Herzog
Jan 15, 2004·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shu-Chun LinYann-Jang Chen

❮ Previous
Next ❯

Citations

Apr 10, 2007·Journal of Molecular Neuroscience : MN·Galynn ZitnikQubai Hu
Nov 28, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ling JiangWenli Ma
Feb 1, 2011·Journal of Molecular Cell Biology·Liqin Du, Alexander Pertsemlidis
Nov 3, 2010·Molecular and Cellular Biology·Christine M Misquitta-AliBenjamin J Blencowe
May 27, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Margherita GrassoMichela A Denti
Sep 18, 2009·The Journal of Investigative Dermatology·Michelle G BotelhoThomas M Jovin
Jul 27, 2007·Experimental and Molecular Pathology·Matthew J ProvenzanoFrederick E Domann
Jan 16, 2013·Proteomics·Seham ChakerPaul G Walfish
Jul 16, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Ju-Hwa LinChia-Che Chang
Feb 7, 2012·The American Journal of Pathology·Vivek VenkataramaniStefan Schweyer
Aug 11, 2016·Technology in Cancer Research & Treatment·Luguang ZhaoShuhuan Fang
Jul 19, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Dongqing ZhangBenkang Shi
Jun 16, 2015·World Journal of Gastroenterology : WJG·Yi-Jun ZhaoJun Yang
Nov 29, 2020·Metabolism: Clinical and Experimental·Yanjun GuoChengfu Xu
May 30, 2019·Pathology, Research and Practice·Shigehiro ItoHironobu Sasano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Related Papers

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Shun-Yao KoTsung-Yun Liu
International Journal of Cancer. Journal International Du Cancer
J Y MengMasashi Koono
Proceedings of the National Academy of Sciences of the United States of America
S LammichF Fahrenholz
© 2022 Meta ULC. All rights reserved