Increased expression of antisense lncRNA SPINT1-AS1 predicts a poor prognosis in colorectal cancer and is negatively correlated with its sense transcript

OncoTargets and Therapy
Chen LiChuan-Xin Wang

Abstract

Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Natural antisense transcripts (NATs) are pervasively expressed in human genome and have been confirmed to contribute to cancer progression. In our study, we aimed to investigate the expression and clinical pertinence of serine peptidase inhibitor, Kunitz type 1 antisense RNA1 (SPINT1-AS1) in CRC. The expression levels of SPINT1-AS1 and the corresponding sense transcript SPINT1 mRNA were analyzed in 150 pairs of CRC tissues and adjacent normal (AN) tissues, along with 45 pairs of preoperative and postoperative serum exosome samples by the strand-specific real-time quantitative polymerase chain reaction. Compared with AN tissues, the expression of SPINT1-AS1 was increased (P<0.001, 3.771 vs 0.980) in CRC tissues, while SPINT1 mRNA expression was decreased in CRC (P<0.001, 0.927 vs 1.165), and there was an obviously negative correlation between SPINT1-AS1 expression and its sense transcript (r=-0.701, P<0.001). SPINT1-AS1 yielded an area under the receiver operating characteristic curve value of 0.865 (95% confidence interval, 0.821-0.902) for discriminating CRC tissues from AN tissues. Moreover, high SPINT1-AS1 expression was correlated with regi...Continue Reading

Citations

Nov 18, 2018·Cancers·Bernadette NeveIsabelle Van Seuningen
Nov 28, 2020·Pathology, Research and Practice·Tongzhou ZhouShukui Wang
Jan 12, 2021·Oxidative Medicine and Cellular Longevity·Xia Qi-DongShao-Gang Wang
Jan 26, 2021·OncoTargets and Therapy·Miao DaShuwen Han
Mar 13, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hye-Mi ChoiSun Shim Choi
Mar 16, 2021·Frontiers in Oncology·Zhiming LiaoChunlin Ou
Apr 16, 2021·Pathology, Research and Practice·Soudeh Ghafouri-FardMohammad Taheri
Aug 6, 2021·Frontiers in Cell and Developmental Biology·Hongjuan SongLiping Liu
Aug 31, 2021·World Journal of Gastrointestinal Oncology·Ru SunChun-Lin Ou

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BETA
surgical resection

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MedCalc
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