Increased expression of CD30 and CD57 molecules on CD4(+) T cells from children with atopic asthma: a preliminary report

Allergy and Asthma Proceedings
Enrique Rojas-RamosRicardo Lascurain

Abstract

T helper type 2 (Th2) cells play an important role in the onset and persistence of allergic airway inflammation. Consequently, many authors have attempted to identify cell surface markers associated with a Th2 phenotype. This work was aimed at correlating CD30 and CD57 expression on CD4(+) T cells with interleukin (IL)-4 production in peripheral blood mononuclear cells (PBMCs) from allergic patients. PBMCs from 17 children with atopic asthma and 12 nonatopic healthy control children were analyzed. The CD28, CD30, CD40L, CD57, CD62L, CD69, IL-4, and IFN-gamma expressions on CD4(+) T cells were determined by double immunofluorescence and flow cytometry in PBMCs ex vivo and after phorbol-12-myristate-13-acetate plus ionomycin (PMA/I) stimulation. An increased percentage of peripheral CD4(+)CD30(+) T cells was observed in asthmatic patients (p < 0.001). In addition, the percentage of CD4(+) T cells expressing IL-4, IFN-gamma, CD30, CD40L, CD57, or CD69 significantly increased (p < 0.01) after PMA/I stimulation, in asthmatic patients. The CD30 expression on CD4(+) T cells from asthmatic patients, after stimulation, correlated with both IL-4 and IFN-gamma production, whereas CD57 expression only correlated with IL-4 production. These...Continue Reading

Citations

Sep 30, 2009·International Archives of Allergy and Immunology·Vincent LombardiOmid Akbari
Dec 18, 2013·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Jonathan S BoomerJonathan M Green
Aug 27, 2016·Clinical Reviews in Allergy & Immunology·Juan J Nieto-FontarigoFrancisco J Salgado
Dec 17, 2008·Current Opinion in Pulmonary Medicine

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