PMID: 7537840May 13, 1995Paper

Increased expression of CD44v6 and CD44v3 in ulcerative colitis but not colonic Crohn's disease

Lancet
W M RosenbergJ I Bell

Abstract

Immune mechanisms, possibly involving cell-surface molecules such as CD44, have been invoked to explain the pathogenesis of inflammatory bowel disease. We used monoclonal antibodies against epitopes encoded within the variable region of CD44 to investigate CD44 isoform expression in colon, small intestine, and liver in patients with various intestinal disorders and in controls. Biopsy samples from patients with ulcerative colitis showed significantly increased epithelial expression of CD44 isoforms containing the v6 and v3 epitopes, detected with antibodies 2F10 and 3G5, respectively. CD44v6 was detected on colonic crypt epithelial cells in 23 of 25 ulcerative colitis samples compared with 3 of 18 colonic Crohn's disease samples (p = 3.0 x 10(-6); odds ratio 57.5 [95% CI 6.83-702]) and 3 of 52 controls (22 normal colon, 10 infective colitis, 2 radiation colitis, and 18 colonic Crohn's disease; p < 1 x 10(-8); odds ratio 199 [25.5-2294]). No significant expression of CD44v6, CD44v3, or CD44v8/9 was found in samples of normal proximal colon from 4 patients with distal ulcerative colitis, whereas samples from the affected area showed staining for CD44v6 and CD44v3. No expression of CD44 variants was found in 15 samples of normal s...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G R ScreatonJ I Bell
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C M ParkerM B Brenner
Oct 1, 1991·The Journal of Experimental Medicine·M S SyI Stamenkovic
Dec 1, 1989·Immunology Today·B F HaynesS M Denning
Apr 1, 1983·Gut·S H SaverymuttuV S Chadwick
Jan 1, 1994·The Journal of Cell Biology·C R MackayU Günthert
Jul 1, 1993·The Journal of Clinical Investigation·D K PodolskyM deBeaumont

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Citations

Aug 22, 1997·International Journal of Cancer. Journal International Du Cancer·J M ChongS Mizuno
Sep 12, 2007·Journal of Clinical Immunology·Ponlatham ChaiyaritMantharop Chaimusig
Jun 18, 1999·Gastroenterology Clinics of North America·B E Sands
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M GivehchianM von Knebel Doeberitz
Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S Weg-RemersA Stallmach
Nov 1, 2000·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·T MatsuuraC Fiocchi
Oct 7, 2006·Current Opinion in Gastroenterology·J A KatzC Fiocchi
Oct 14, 2003·Inflammatory Bowel Diseases·Karel Geboes, Gert De Hertogh
Jan 1, 1997·The British Journal of Ophthalmology·S N ZhuG Duncker
Oct 18, 2012·Investigative Ophthalmology & Visual Science·Tiarnan D L KeenanPaul N Bishop
Oct 12, 2012·International Journal of Cancer. Journal International Du Cancer·Hironori KumagaiShinji Sakuma
Jul 3, 1998·Gastroenterology·C Fiocchi
Jul 27, 1996·Lancet·A KitanoK Kobayashi
Sep 23, 2008·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J MaddenR F Grimble
Aug 10, 2000·Immunological Investigations·S D Reid, A G Pockley
Oct 3, 1998·Clinical Immunology and Immunopathology·S SeiterM Zöller
Sep 3, 2005·Cancer Letters·Yong Geon KimYoung Do Yoo
May 27, 1999·Health Manpower Management·A Mark, P Critten
May 14, 2003·Autonomic Neuroscience : Basic & Clinical·P C Miceli, K Jacobson
May 1, 1997·Scandinavian Journal of Gastroenterology·B Vainer
Aug 26, 1998·Scandinavian Journal of Gastroenterology·D ElewautE M Veys
Jun 11, 2014·Nature Reviews. Gastroenterology & Hepatology·Evropi TheodoratouGordan Lauc
Nov 30, 2000·The American Journal of Gastroenterology·A Ikehata, N Tomichi
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K A FitzgeraldL A O'Neill
Oct 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer C BrazilNancy A Louis
Mar 21, 2001·Critical Reviews in Clinical Laboratory Sciences·R J FarrellM A Peppercorn
Sep 23, 2003·European Journal of Gastroenterology & Hepatology·Douglas C MacdonaldWilliam Rosenberg
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S L BlassC A Hunter
Oct 15, 1998·Transplantation·S SeiterM Zöller

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