Increased expression of CXCR3 and its ligands in patients with vitiligo and CXCL10 as a potential clinical marker for vitiligo

The British Journal of Dermatology
X X WangL H Xiang

Abstract

Vitiligo is a skin disorder characterized by loss of melanocytes from the epidermis. A recent study reported that CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo, but there is very limited clinical data regarding this issue and little is known about the dynamic changes or correlations with disease severity of these chemokines throughout the disease course. To present clinical data that supports and identifies the pathway of CXCR3 and its ligands in T-lymphocytic cell recruitment in vitiligo. Cytometric bead array, flow cytometry, quantitative real-time polymerase chain reaction and immunohistology were used to examine their systemic and local expression in 80 patients with vitiligo and 40 controls. We showed that serum CXCL9 and CXCL10 were significantly elevated in patients with vitiligo and were higher in patients in progressive stages than in stable stages. The relative expression of CXCR3 mRNA in peripheral blood mononuclear cells was higher in vitiligo. There were higher percentages of both circulating CXCR3(+) CD4(+) and CXCR3(+) CD8(+) T cells in patients with progressive vitiligo compared with controls, while only the expression of CXCR3(+) CD8(+) T cells increased i...Continue Reading

References

Mar 8, 2003·Pigment Cell Research·Katia OngenaeJean-Marie Naeyaert
May 15, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Anna Wańkowicz-KalińskaPranab K Das
May 20, 2003·Pigment Cell Research·Asem AlkhateebRichard A Spritz
Jul 21, 2005·Pigment Cell Research·Greggory LabergeRichard A Spritz
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antje RhodeUrs Christen
May 24, 2006·Clinical and Experimental Dermatology·J WenzelT Tüting
Oct 10, 2006·Journal of Cutaneous Pathology·Joerg WenzelThomas Tüting
Jan 26, 2007·Pigment Cell Research·Alain TaïebUNKNOWN VETF Members
Mar 19, 2008·Archives of Dermatology·Stanca A BirleaRichard A Spritz
Oct 8, 2008·Archives of Dermatological Research·Zheng ZhangXue-Jun Zhang
Feb 27, 2009·The Journal of Investigative Dermatology·Jasper G van den BoornRosalie M Luiten
May 29, 2009·The Journal of Investigative Dermatology·Anke S LonsdorfAlexander H Enk
Sep 18, 2009·Annals of the New York Academy of Sciences·Stéphanie LacotteHélène Dumortier
Jan 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Randal K GreggVictor H Engelhard
Jul 23, 2011·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Richard A Spritz
Oct 14, 2011·The Journal of Investigative Dermatology·Richard A Spritz
Nov 25, 2011·The Journal of Investigative Dermatology·Fengying Shi, Gisela F Erf
Feb 24, 2012·The Journal of Investigative Dermatology·Caroline G McPheeJohn P Sundberg
Mar 16, 2012·Pigment Cell & Melanoma Research·K EzzedineUNKNOWN Vitiligo Global Issue Consensus Conference Panelists
Dec 21, 2012·The British Journal of Dermatology·A GeyK Ezzedine
Jun 20, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mitesh DwivediRasheedunnisa Begum
Oct 11, 2013·Dermatology : International Journal for Clinical and Investigative Dermatology·Vaneeta M ShethAbrar A Qureshi
Nov 19, 2013·Current Opinion in Immunology·Jillian M RichmondJohn E Harris
Feb 14, 2014·Science Translational Medicine·Mehdi RashighiJohn E Harris
Feb 18, 2014·International Journal of Dermatology·Marwa AbdallahRiham Galal
Mar 8, 2014·Dermatology : International Journal for Clinical and Investigative Dermatology·Vito IngordoLuigi Naldi
Jul 1, 2014·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·I RuffilliA Antonelli
Sep 26, 2014·Postȩpy dermatologii i alergologii·Rafał Czajkowski, Kaja Męcińska-Jundziłł
Dec 17, 2014·Cytokine & Growth Factor Reviews·Katrien Van RaemdonckSofie Struyf
Jan 19, 2015·Lancet·Khaled EzzedineNanja van Geel

❮ Previous
Next ❯

Citations

Jun 19, 2016·The British Journal of Dermatology·M Rashighi, J E Harris
Oct 13, 2016·The International Journal of Biochemistry & Cell Biology·Chunya NiFlorian Gruber
Oct 21, 2016·Current Opinion in Immunology·James P Strassner, John E Harris
Nov 20, 2016·Pigment Cell & Melanoma Research·Amal MaouiaThierry Passeron
Jan 28, 2017·The Journal of Investigative Dermatology·Jillian M RichmondJohn E Harris
Mar 6, 2017·Journal of the American Academy of Dermatology·James P StrassnerJohn E Harris
Mar 21, 2017·Dermatologic Clinics·Mehdi Rashighi, John E Harris
Mar 21, 2017·Dermatologic Clinics·Tasneem F Mohammad, Iltefat H Hamzavi
Dec 2, 2017·The British Journal of Dermatology·R Speeckaert, N van Geel
Apr 13, 2019·Immunological Reviews·Jillian M RichmondJohn E Harris
May 8, 2019·Pigment Cell & Melanoma Research·Reinhart SpeeckaertNanja van Geel
Jun 21, 2019·Biological & Pharmaceutical Bulletin·Yiping ZhuAie Xu
Nov 17, 2019·International Journal of Molecular Sciences·Cristina Maria FaillaStefania D'Atri
Feb 6, 2020·Annual Review of Immunology·Michael L FrisoliJohn E Harris
Oct 17, 2017·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Meurer, P Ceric-Dehdari
Nov 3, 2017·Pigment Cell & Melanoma Research·Marwa AbdallahUNKNOWN Egyptian Vitiligo Group
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Qiancheng DengRong Xiao
Nov 9, 2017·The Journal of Dermatology·Lingling YangAi-E Xu
Dec 6, 2018·Frontiers in Immunology·Liisi RaamKülli Kingo
May 23, 2018·International Journal of Molecular Sciences·Anuradha Bishnoi, Davinder Parsad
Nov 30, 2020·Experimental Dermatology·Jaime Piquero-CasalsLuis Puig
Jan 7, 2021·The Journal of Dermatology·Christina Bergqvist, Khaled Ezzedine
Nov 23, 2019·Dermatologic Clinics·Raheel Zubair, Iltefat H Hamzavi
Oct 19, 2019·Microbial Pathogenesis·Lingzhi NiuYajuan Zheng
Oct 24, 2020·Scientific Reports·Wei LiuDong-Lai Ma
Mar 20, 2021·Frontiers in Immunology·Erica L Katz, John E Harris
Apr 27, 2021·Expert Opinion on Drug Safety·Janny E LommertsRosalie M Luiten
Dec 24, 2018·The Journal of Allergy and Clinical Immunology·Tali CzarnowickiEmma Guttman-Yassky
Dec 27, 2019·The Journal of Investigative Dermatology·Clément JacqueminKatia Boniface
Jul 16, 2021·Photodermatology, Photoimmunology & Photomedicine·Fuquan LinAi-E Xu
Aug 28, 2021·International Journal of Molecular Sciences·Andrea D'ArinoPaolo Iacovelli
Sep 11, 2021·Autoimmunity Reviews·Binod K Khaitan, Tekumalla Sindhuja
Mar 11, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Christina Bergqvist, Khaled Ezzedine
Nov 16, 2021·Pigment Cell & Melanoma Research·Xinya XuLeihong Flora Xiang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.