Increased expression of cyclin A1 protein is associated with all-trans retinoic acid-induced apoptosis

The International Journal of Biochemistry & Cell Biology
Jenny EkbergJenny Liao Persson

Abstract

Deregulated cell growth and inhibition of apoptosis are hallmarks of cancer. All-trans retinoic acid induces clinical remission in patients with acute promyelocytic leukemia by inhibiting cell growth and inducing differentiation and apoptosis of the leukemic blasts. An important role of the cell cycle regulatory protein, cyclin A1, in the development of acute myeloid leukemia has previously been demonstrated in a transgenic mouse model. We have recently shown that there was a direct interaction between cyclin A1 and a major all-trans retinoic acid receptor, RAR alpha, following all-trans retinoic acid treatment of leukemic cells. In the present study, we investigated whether cyclin A1 might be involved in all-trans retinoic acid-induced apoptosis in U-937 leukemic cells. We found that all-trans retinoic acid-induced apoptosis was associated with concomitant increase in cyclin A1 expression. However, there was no induction of cyclin A1 mRNA expression following the all-trans retinoic acid-induced apoptosis. Treatment of cells with a caspase inhibitor was not able to prevent all-trans retinoic acid-induced up-regulation of cyclin A1 expression. Interestingly, induced cyclin A1 expression in U-937 cells led to a significant increa...Continue Reading

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Citations

Nov 22, 2007·International Journal of Cancer. Journal International Du Cancer·Barbara WegielJenny Liao Persson
Jul 20, 2007·Differentiation; Research in Biological Diversity·Nigel P Mongan, Lorraine J Gudas
Dec 31, 2020·International Journal of Molecular Sciences·Laura MoscaAnnapina Russo

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