Increased expression of cyclin D1 in the adult rat brain following kainic acid treatment

Neuroreport
W LiuS S Schreiber

Abstract

Recent evidence has implicated aberrant cell cycle regulation as a possible mechanism of apoptosis in non-dividing cells. We previously demonstrated increased expression of the p53 tumor suppressor gene, a prominent cell cycle regulator, in apoptotic neurons. Here we investigated the potential involvement of cyclin D1, a G1 phase cell cycle protein under p53 regulation, in kainic acid-mediated neuronal degeneration. Adult male Sprague-Dawley rats were treated systemically with kainic acid and sacrificed between 1 h and 5 days following seizure onset. Cyclin D1 expression was studied by Western blot analysis and immunohistochemistry using a rabbit polyclonal anti-cyclin D1 antibody. In untreated control rats low levels of cyclin D1 expression were detected in multiple brain regions. Between 8 and 16 h after the onset of kainic acid-induced seizures, increased cyclin D1 immunoreactivity was observed in vulnerable hippocampal pyramidal cells. Five days after seizure onset increased cyclin D1 expression was evident in reactive astrocytes. These results support a role for cyclin D1 in certain neuronal death pathways, and suggest that cyclin D1 has multiple and cell type-specific functions in the central nervous system.

Citations

Jan 13, 2004·Neurotoxicity Research·Christopher A McPhersonG Jean Harry
Aug 23, 2002·Pharmacology & Therapeutics·Michael O'HareDavid S Park
Jul 17, 1999·Brain Research. Molecular Brain Research·J A NapieralskiT K McIntosh
Mar 15, 2001·Neurochemistry International·S Zagulska-SzymczakL Kaczmarek
May 5, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·T Arendt
Aug 10, 2000·Neuropathology and Applied Neurobiology·T HayashiK Abe
Aug 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J P MacManus, M D Linnik
Feb 2, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fuhu WangDavid S Park
Sep 27, 2015·Toxicon : Official Journal of the International Society on Toxinology·Shabnam CheraghiHassan Malekinejad
Feb 15, 2015·Brain : a Journal of Neurology·Wei-Hsiang LinRichard A Baines
Jan 24, 2007·Biochimica Et Biophysica Acta·J RashidianD S Park
Mar 17, 1999·Biochimica Et Biophysica Acta·W G Tatton, C W Olanow
Dec 8, 2004·Progress in Brain Research·Thomas Arendt
Jan 13, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·D S Schrump, D M Nguyen
Jun 17, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y TuJ P MacManus
Jul 28, 2005·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J M StreitzA C Aufderheide
Jan 24, 2003·Expert Opinion on Therapeutic Targets·Fuhu WangDavid S Park
Mar 27, 2021·Toxicology·Sunny O AbarikwuLuiz R de França

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.