Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis

Gastroenterology
N ArberP R Holt

Abstract

Cyclin D1 gene amplification and/or overexpression occurs in several human cancers. The level of expression of cyclin D1 protein during the multistage process of human colon carcinogenesis was determined. Cyclin D1 protein abundance was determined by immunostaining samples of normal colonic mucosa(n=23), transitional normal mucosa adjacent to adenomas or adenocarcinomas (n=41), hyperplastic polyps (n=8), adenomatous polyps (=35), and adenocarcinomas (n=27), using a polyclonal anti-human cyclin D1 antibody. Cyclin D1 nuclear staining occurred in 30% of adenocarcinomas and 34% of adenomatous polyps but not in hyperplastic polyps or normal or transitional mucosa. Nuclear staining did not correlate with sex, age, size, or dysplasia of the adenomatous polyps or with differentiation and Dukes' staging of the adenocarcinomas. Left-sided colon neoplasms showed nuclear staining more frequently than those right-sided lesions. Diffuse or supranuclear cytoplasmic staining occurred in about one third of hyperplastic polyps, adenomas, and adenocarcinomas and in transitional mucosa adjacent to adenocarcinoma. Increased nuclear expression of cyclin D1 occurs in around one third of colonic tumors as an early event during multistage process of c...Continue Reading

Citations

Jun 3, 2005·Thyroid : Official Journal of the American Thyroid Association·Cheryl A PickettMary P Bronner
Sep 21, 2007·Molecular Biology of the Cell·Miriam HuertaEsther López-Bayghen
Jun 13, 1998·Molecular Pathology : MP·R Donnellan, R Chetty
Jun 25, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shuji OginoCharles S Fuchs
Nov 24, 2004·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·D TonchevaB Zaharieva
Sep 24, 2004·BMC Gastroenterology·Abeer A BahnassyMostafa El-Serafi
Jan 24, 2006·World Journal of Surgical Oncology·Gregory KouraklisCrysoula Sioka
Nov 3, 2012·PloS One·Daniel SlivaShailesh Dudhgaonkar
Sep 30, 2010·Immunotherapy·Nela Klein-GonzálezMichael S von Bergwelt-Baildon
Aug 24, 2013·International Journal of Molecular Sciences·Dora ColussiLuigi Ricciardiello
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kristina SchoonjansJohan Auwerx
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·M ShtutmanA Ben-Ze'ev
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·S Y LinM C Hung
Apr 18, 2009·Journal of Gastrointestinal Cancer·Nora Manoukian ForonesIsmael Dale Cotrim Guerreiro da Silva
Mar 26, 2011·Expert Review of Vaccines·Michael S von Bergwelt-BaildonClemens M Wendtner
Jan 10, 2003·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Laurie A DavidsonRobert S Chapkin
Jan 5, 2013·Critical Reviews in Oncology/hematology·William K K WuJun Yu
Sep 9, 2009·International Journal of Radiation Oncology, Biology, Physics·Santosh K SandurSunil Krishnan
Apr 3, 2007·International Journal of Radiation Oncology, Biology, Physics·Alexandre Ho-Pun-CheungEvelyne Lopez-Crapez
Mar 8, 2005·International Journal of Cancer. Journal International Du Cancer·Kenichiro DoiShoji Fukushima
Oct 1, 2004·Molecular Carcinogenesis·Mark D GustavsonLynn M Matrisian
Jan 31, 2003·Genes, Chromosomes & Cancer·Jan J MolenaarHuib N Caron
Feb 13, 2009·Journal of Cellular and Molecular Medicine·Jie LiangDaiming Fan
Feb 14, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Johan BondiIsa R K Bukholm
Aug 19, 2005·International Journal of Cancer. Journal International Du Cancer·William M GradySanford D Markowitz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.