Increased expression of cytokeratins 8, 18 and vimentin in the invasion front of mucosal squamous cell carcinoma

The Journal of Pathology
H E SchaafsmaF C Ramaekers

Abstract

The immunohistochemical expression patterns of cytokeratins 8 and 18 and vimentin were examined in frozen sections of 120 human mucosal squamous cell carcinomas with special emphasis on the topological distribution in the tumour. This was done in order to evaluate in squamous cell carcinoma a particular expression pattern observed recently by us in transitional cell carcinoma of the urinary tract and designated as an 'interface phenomenon'. This phenomenon implying maximum expression of cytokeratins 8 and 18 at the tumour front, and to a lesser extent also in areas of intratumorous stroma contact, was also found in about 50 per cent of the squamous cell carcinomas examined. It was even found for vimentin, which contrasted with transitional cell carcinoma. The percentages of occurrence of the phenomenon varied for the different sites of origin of the tumour. Tumour grade did not influence the results. These findings further support the idea that invasive carcinoma cells interacting with the stromal micro-environment display a characteristic intermediate filament phenotype that deviates from the pattern expected on the basis of their direction of differentiation. These changes might reflect phenotype involved in invasive, migrati...Continue Reading

References

Jan 1, 1995·Cell Motility and the Cytoskeleton·J M Andreoli, K T Trevor
Dec 1, 1996·Cancer Metastasis Reviews·R G OshimaC Caulín
May 1, 1994·European Journal of Cancer. Part B, Oral Oncology·P R Morgan, L Su
Dec 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K HaustermansA C Begg
Oct 9, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yoko FukunagaToshihiko Ishida
Dec 16, 1998·The American Journal of Surgical Pathology·T T Kuo, J K Chan
Jul 1, 1996·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L SuE B Lane
Oct 6, 1997·American Journal of Respiratory Cell and Molecular Biology·Y W ChuC W Wu
Jun 8, 1999·The Journal of Clinical Investigation·M L CasanovaJ L Jorcano
Apr 19, 2013·Experimental Hematology & Oncology·Patrizia CerutiFrancesco Novelli
Aug 8, 2014·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Saleha JamadarSadhana Shenoy
Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·L A van der VeldenW Kuijpers
Dec 15, 2015·Molecular Biology of the Cell·Brigid M BleakenJanice L Walker
Feb 13, 2013·Experimental Cell Research·Vivien J Coulson-ThomasHelena B Nader
Sep 19, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y-F QiaoZ-T Yu
Oct 16, 2009·The International Journal of Biochemistry & Cell Biology·Wei-Guo HuangZhi-Qiang Xiao
Jan 2, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·R B Presland, B A Dale
Feb 28, 2002·The Annals of Otology, Rhinology, and Laryngology·Raanan Cohen-KeremMichal A Rahat
Nov 13, 2004·The Annals of Otology, Rhinology, and Laryngology·Raanan Cohen-KeremIrit Elmalah
Jul 25, 2018·Histochemistry and Cell Biology·Hayan YiNam-On Ku
Nov 25, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·F G SchollM Quintanilla

Citations

Dec 1, 1990·Laryngo- rhino- otologie·F WallnerM Altmannsberger
Nov 1, 1991·The Journal of Investigative Dermatology·A C MarkeyI M Leigh
Dec 1, 1988·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·S C Henzen-LogmansC J Meyer
Jun 1, 1989·The Journal of Pathology·W A Raymond, A S Leong
Oct 1, 1989·Differentiation; Research in Biological Diversity·J KolegaT T Sun
Mar 1, 1989·Pathology, Research and Practice·K Donhuijsen, S Schulz
Jan 1, 1988·Journal of Cell Science. Supplement·P M Sharpe, M W Ferguson
Sep 1, 1984·Journal of Clinical Pathology·C A MakinW F Bodmer

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