Increased expression of endogenous xenotropic murine retrovirus by treatment with the tetrapeptides, tuftsin and kentsin

The Journal of General Virology
W A Suk, C W Long

Abstract

Enhancement of endogenous xenotropic virus expression has been found upon treatment with tetrapeptides of a high-passage clone of Balb/c (K-Balb) mouse cells transformed with Kirsten sarcoma virus. Tuftsin (Thr-Lys-Pro-Arg) and kentsin (Thr-Pro-Arg-Lys) increased the expression of virus that was infectious for rat, but not mouse, cells in a concentration-dependent fashion. The enhancement of virus expression by the tetrapeptides was proportional to the spontaneous release of virus. The infectivity of the enhanced virus was neutralized by goat anti-RLV gp70 serum. Actinomycin D inhibited the induction of virus, suggesting that enhanced expression required de novo RNA synthesis. The effects observed using K-Balb cells offer an opportunity to study the many biological effects of these peptides in a fibroblast culture system.

Citations

May 1, 1986·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·W A Suk, C W Long
Aug 28, 1999·Peptides·I Z Siemion, A Kluczyk
Jan 1, 1989·Critical Reviews in Biochemistry and Molecular Biology·M Fridkin, V A Najjar
Jan 1, 1983·Annals of the New York Academy of Sciences·J Martinez, F Winternitz
Jan 1, 1983·Annals of the New York Academy of Sciences·W A Suk, C W Long
Aug 1, 1982·European Journal of Biochemistry·G PüschelE Heymann
Jan 2, 1984·Klinische Wochenschrift·E Heymann, R Mentlein

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