Abstract
Lung adenocarcinoma is the leading cause of cancer-related death worldwide. The aim of the present study was to investigate the potential function of endoplasmic reticulum protein 29 (ERp29) in lung adenocarcinoma. We examined the expression of ERp29 in 75 patients with lung adenocarcinoma by immunohistochemical analysis, as well as its association with clinicopathological features. We further tested the effects of inhibiting ERp29 on cell proliferation, migration ability, and chemosensitivity to gemcitabine in human lung adenocarcinoma cell lines. ERp29 was significantly overexpressed in lung adenocarcinoma when compared with matched nontumor tissues. However, we did not observe significant associations of ERp29 with any of the clinicopathologic characteristics, including sex, age, differentiation, tumor, node, and metastasis stage, T stage, and lymph node metastasis. Downregulation of ERp29 by small interfering RNA did not affect cell growth, but impaired cell migration of lung adenocarcinoma cells. Inhibition of ERp29 significantly enhanced the chemosensitivity of lung adenocarcinoma cells to gemcitabine. These results support a probable treatment combination of gemcitabine and inhibition of ERp29 overexpression for lung ade...Continue Reading
References
Sep 17, 1998·European Journal of Biochemistry·D M FerrariH D Söling
May 9, 2006·Antioxidants & Redox Signaling·Souren Mkrtchian, Tatyana Sandalova
Oct 3, 2006·The American Journal of Dermatopathology·Christos CheretisHelen Koutselini
Apr 4, 2008·Journal of Neurochemistry·April A DukesTeresa G Hastings
Apr 9, 2008·Molecular Carcinogenesis·Souren MkrtchianHippokratis Kiaris
Sep 20, 2008·Journal of Radiation Research·Bo ZhangZhongmin Zou
Dec 17, 2008·Journal of Molecular Biology·Naomi N BarakDavid M Ferrari
Jun 2, 2009·Journal of Ethnopharmacology·Yu-Chiang HungYann-Lii Leu
Sep 23, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·I Fon BambangDaohai Zhang
Sep 14, 2010·Experimental Cell Research·Daohai Zhang, Thomas C Putti
Oct 6, 2010·The International Journal of Biochemistry & Cell Biology·Daohai Zhang, Des R Richardson
Apr 12, 2011·Medical Oncology·Lin QiYongquan Tian
May 1, 2012·Oncogene·I F BambangD Zhang
Apr 6, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Lian-Wen YuanZhu-Lin Yang
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jun 12, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yong-Jian DengYan-Qing Ding
Aug 1, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Sep 11, 2014·Nature·Eric Bender
Dec 5, 2014·PloS One·Bei ChenWeimin Zhang