Increased expression of endothelial cell adhesion molecules due to mediator release from human foreskin mast cells stimulated by autoantibodies in chronic urticaria sera

The Journal of Investigative Dermatology
Kwang Hoon LeeJai Youl Ro

Abstract

Histamine-releasing antibodies that act against the epitope of the alpha chain of Fc(epsilon)RI (anti-Fc(epsilon)RI(alpha) antibody) that may affect pathogenesis in serum of patients with chronic urticaria. We assessed the capability of anti-Fc(epsilon)RI(alpha) antibody in sera from patients with chronic urticaria to release histamine and cytokines, and to induce the expression of endothelial cell adhesion molecules. We also assessed the release of inflammatory mediators from cultured foreskin mast cells, and expression of endothelial cell adhesion molecules on human dermal microvascular endothelial cells. Cells were pretreated with mast cell-conditioned media: culture media of mast cells treated with sera from chronic urticaria patients containing anti-Fc(epsilon)RI(alpha) antibody. Histamine release from human foreskin mast cells challenged with sera, increased after both 20 min and 16 h intervals. Leukotriene D4 release also increased at both 20 min and 16 h. Tumor necrosis factor-alpha increased significantly in foreskin mast cell culture challenged with sera of chronic urticaria patients. After the stimulation of human dermal microvascular endothelial cells with the conditioned media, the expression of intercellular cell ...Continue Reading

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Citations

Oct 23, 2012·Archives of Medical Research·Mohamed Kamel SabryAnnie Arek-Ohanessian
Apr 30, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A P Kaplan, M Greaves
May 4, 2004·Immunology and Allergy Clinics of North America·Clive E H Grattan
Aug 27, 2015·Clinical and Translational Allergy·Marta Ferrer
Aug 15, 2014·Dermatology Research and Practice·Sanjiv Jain
Sep 10, 2004·The Journal of Allergy and Clinical Immunology·Allen P Kaplan
Oct 26, 2013·International Archives of Allergy and Immunology·Ilaria PuxedduPaola Migliorini
Mar 13, 2010·Allergy, Asthma & Immunology Research·Nami Shrestha PalikheHae-Sim Park
Jan 4, 2013·The World Allergy Organization Journal·Mario Sánchez-BorgesUNKNOWN WAO Scientific and Clinical Issues Council
May 1, 2021·International Journal of Molecular Sciences·Martin VossAnne Dudeck

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