Increased expression of formin-like 3 contributes to metastasis and poor prognosis in colorectal carcinoma

Experimental and Molecular Pathology
Yuanfeng ZengHong-Bo Xin

Abstract

Formin-like 3 (FMNL3), a member of diaphanous-related formins subfamily, plays an important role in cytoskeleton reorganization, cell adhesion and cancer cell invasion in vitro. This study aimed to explore the expression of FMNL3 in colorectal carcinoma (CRC) cell-lines and tissues, and further evaluate its prognostic value and correlation with the clinicopathological parameters, and also investigate the effects of FMNL3 gene silencing on the growth and metastasis of CRC in vivo. Immunohistochemical analysis showed that FMNL3 protein was distributed in a punctuate aggregation pattern and located mainly in the cytoplasm of glandular cavity side, close to the nucleus of CRC cells. The positive rate of FMNL3 expression was 87.5% (84/96) in CRC, which was significantly higher than that in adjacent normal mucosa (30%, 9/30). Moreover, FMNL3 protein expressed far more in primary CRC with metastasis and corresponding lymph nodes metastatic CRC than in primary CRC without metastasis. Increased expression of FMNL3 was closely correlated with tumor size, differentiation, serosal invasion, and both lymph node metastasis and distant metastasis. However, it was not correlated with patients' age and gender. According to Kaplan-Meier survival...Continue Reading

References

Feb 1, 1997·The Surgical Clinics of North America·K W MillikanA Doolas
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 10, 2003·International Journal of Oncology·Masuko Katoh, Masaru Katoh
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Labile Togba SoumaoroKenichi Sugihara
Nov 19, 2005·Cancer Biology & Therapy·Mercedes Martín-RufiánFrancisco J Alonso
Jun 3, 2006·Developmental Cell·Jan Faix, Robert Grosse
Jul 22, 2006·Annals of Surgery·Sylvain ManfrediAnne-Marie Bouvier
Mar 22, 2007·Annual Review of Biochemistry·Bruce L Goode, Michael J Eck
Apr 3, 2007·Current Biology : CB·Kathryn M EisenmannArthur S Alberts
Jun 19, 2007·Genes & Development·Thomas M KitzingRobert Grosse
Sep 1, 2007·Nature Cell Biology·Andreas Wodarz, Inke Näthke
Sep 25, 2007·Nature Reviews. Cancer·Erik Sahai
Nov 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Lanlan ShenJean-Pierre J Issa
Jul 31, 2008·International Journal of Colorectal Disease·Xi-Ling ZhuYan-Qing Ding
Sep 17, 2008·Cancer Research·Megumi IiizumiKounosuke Watabe
Sep 24, 2010·Cytoskeleton·Elizabeth S HarrisHenry N Higgs
Nov 13, 2010·Molecular Cancer Research : MCR·Yufa LiLi Liang
Apr 21, 2011·The Journal of Pathology·Xi-Ling ZhuLi Liang
May 18, 2011·The Journal of Cell Biology·Francisco M VegaAnne J Ridley
Jun 16, 2011·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Sanjay Harrison, Harrison Benziger
Jan 26, 2012·Journal of Cell Science·Clare HetheridgeHarry Mellor
May 18, 2012·EMBO Molecular Medicine·Martin H HagerMichael R Freeman
Jul 14, 2012·Bioscience, Biotechnology, and Biochemistry·Koko MoriyaToshihiko Utsumi
Oct 10, 2013·International Journal of Cancer. Journal International Du Cancer·Yuan-Na LinSabine Windhorst
Jan 16, 2014·Indian Journal of Surgical Oncology·Mary L GuyeGagandeep Singh
Feb 28, 2014·World Journal of Gastroenterology : WJG·Fabio CoppedèLucia Migliore
Oct 9, 2014·Oncology Letters·Hirofumi YamamotoMasaki Mori
Nov 28, 2014·Molecular Biology of the Cell·Timothy J GauvinHenry N Higgs

❮ Previous
Next ❯

Citations

Jan 7, 2016·Trends in Biochemical Sciences·Katharina Grikscheit, Robert Grosse
Mar 23, 2017·Nature Communications·Frieda KageKlemens Rottner
Apr 8, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Jiameng LiuChongjin Feng
Sep 1, 2016·BMC Cell Biology·Christine PéladeauJohn W Copeland
Dec 22, 2019·International Journal of Molecular Sciences·Nayuta HigaKazunori Arita
Sep 20, 2018·World Journal of Gastroenterology : WJG·Yuan-Feng ZengMin Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Related Papers

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Zhenqian WuYu Wang
International Journal of Clinical and Experimental Pathology
Xuebing YanYu Wang
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Da-Wei ChenXiao-Xiao Jiang
APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Yanfeng NiuJun Liu
© 2022 Meta ULC. All rights reserved