Increased expression of galanin in the rat superior cervical ganglion after pre- and postganglionic nerve lesions

Experimental Neurology
X ZhangT Hökfelt

Abstract

Using immunohistochemistry the expression of galanin (GAL) and galanin message-associated peptide (GMAP) in the superior cervical ganglion (SCG) was investigated 2, 4, 7, and 14 days after unilateral transection of the cervical sympathetic trunk (decentralization) or after cutting the external and internal carotid nerves (axotomy), as well as 7 days after removal of parotid gland tissue. In control SCGs including the sympathetic trunk and the carotid nerves, very few neurons and fibers were GAL/GMAP-positive. Two and 7 days after decentralization, about 5% of all counted neuron profiles in the ipsilateral SCG were GAL/GMAP immunoreactive. Immunoreactive cell bodies were distributed throughout the SCG, with a greater number in the most caudal portion of the ganglion. Many GAL/GMAP-positive nerve fibers were observed in the whole SCG, with strongly fluorescent bundles of immunoreactive fibers accumulated at the caudal end of the SCG. Several GAL/GMAP-immunoreactive nerve fibers were seen ipsilaterally in the external carotid nerve, whereas only a few positive fibers could be observed in the internal carotid nerve. About 2% of all counted neuron profiles in SCGs ipsilateral to decentralization still contained GAL/GMAP-immunoreacti...Continue Reading

Citations

Dec 19, 2013·ISRN Neurology·Pablo R Brumovsky
Jul 16, 2003·The European Journal of Neuroscience·Bartłomiej Szulczyk, Paweł Szulczyk
Apr 16, 2004·Journal of Neurobiology·Kristen L BoeshoreRichard E Zigmond
Feb 1, 1996·Molecular Neurobiology·S R Whittemore, E Y Snyder
Mar 13, 2009·Developmental Neurobiology·Beth A HabeckerRichard E Zigmond
Sep 22, 1995·Regulatory Peptides·J N Crawley

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