PMID: 11345140May 10, 2001Paper

Increased expression of glutathione S-transferase-pi in the islets of patients with primary chronic pancreatitis but not secondary chronic pancreatitis

Pancreas
Alexis B UlrichP M Pour

Abstract

The mechanism of tissue alteration in chronic pancreatitis (CP) is still unclear. Different hypotheses have been discussed, including increasing oxidant stress in the acinar cells, often as a result of exposure to xenobiotics. To evaluate the role of oxidative stress in CP, the authors investigated the expression of the drug-metabolizing phase II enzyme, glutathione S-transferase-pi (GST-pi), in the pancreatic tissue of patients with CP and compared it with the healthy pancreatic tissue from age-matched donors. Pancreatic tissue from patients with secondary CP resulting from ductal obstruction by pancreatic cancer (PC) was also examined. The percentage of cells immunoreacting with anti-GST-pi was counted within 15 randomly selected islets in each slide of the three groups. In all specimens, ductal and ductular cells, and in PC, cancer cells, expressed GST-pi in a moderate intensity. Acinar cells did not stain. Various numbers of islet cells in each of the three groups were stained strongly. More islet cells expressed GST-pi in CP (42%) than in healthy pancreatic tissue (16%, p < 0.001) or PC (17%, p < 0.001). Our results imply an important role of islet cells in the metabolism of substances, which are the substrate for GST-pi, ...Continue Reading

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Citations

Apr 30, 2003·Pancreas·Murat Saruc, Parviz M Pour
Jan 7, 2004·Pancreas·Thomas SchaarschmidtRainer Wacke
Oct 16, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Parviz M PourSurinder K Batra
Nov 19, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Jens StandopParviz M Pour
Dec 2, 2004·World Journal of Surgical Oncology·Christophoros N ForoulisAthanassios Lioupis
Jul 23, 2005·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Mariette VerlaanJoost P H Drenth
Jun 10, 2003·American Journal of Medical Genetics. Part a·Mariette VerlaanJoost P H Drenth
Aug 2, 2005·Alcohol·Vay Liang W GoStephen J Pandol
Jul 10, 2004·Biochemical Pharmacology·Diane J Lees MurdockChristopher R Barnett
Aug 23, 2012·PLoS Genetics·Stephen C J ParkerElliott H Margulies
Apr 13, 2002·Toxicologic Pathology·Alexis B UlrichParviz M Pour
Sep 29, 2006·World Journal of Gastroenterology : WJG·Mariette VerlaanJoost P H Drenth

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