Increased expression of IL-6 family members in tendon pathology.

Rheumatology
Kirsten LegerlotzGraham P Riley

Abstract

Histological examination of pathological tendon generally does not reveal signs of inflammation. However, the inflammatory cytokine IL-6 has been shown to be expressed in ruptured rotator cuff tendon. The aim of this study was to investigate the expression of IL-6 family members in painful posterior tibialis tendon (PTT) and in painful and ruptured Achilles tendon (AT) compared with normal tendon. AT samples were obtained from cadavers (normal) or from patients undergoing surgical procedures to treat chronic painful tendinopathy or ruptured tendon. PTT samples were obtained from patients undergoing surgery for other reasons (normal) and from patients with PTT dysfunction (painful). Total RNA was extracted and mRNA expression was analysed by quantitative real-time PCR. Collagen type I α-chain I (COL1A1) expression was increased in both painful PTT and AT compared with normal. Ciliary neurotrophic factor levels were increased in painful PTT only. In the painful AT, cyclooxygenase-2 (COX2) and IL-6 expression increased compared with normal. In the ruptured AT, levels of VEGF A, COX2, oncostatin-M, leukaemia inhibitory factor and IL-6 expression were higher compared with both normal and painful AT. IL-6R expression decreased in bot...Continue Reading

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References

Jan 1, 1993·Rheumatology International·G J Carroll, M C Bell
Jun 23, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·D IrelandG Riley
Oct 31, 2001·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·M SkutekU Bosch
Nov 17, 2001·Virchows Archiv : an International Journal of Pathology·T PufeR Mentlein
Jun 20, 2002·Clinical Orthopaedics and Related Research·Sai Chuen FuChrister Gustav Rolf
Oct 14, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Håkan AlfredsonUlf H Lerner
Apr 22, 2008·Clinical Orthopaedics and Related Research·Evgenia KarousouNicola Maffulli
May 7, 2008·Clinical Orthopaedics and Related Research·Alexander ScottVincent Duronio
May 13, 2008·Clinical Orthopaedics and Related Research·Hui B SunEvan L Flatow
Jul 16, 2009·Scandinavian Journal of Medicine & Science in Sports·D BringP Ackermann
Nov 7, 2009·Journal of Applied Physiology·Shruti Arya, Kornelia Kulig
Oct 13, 2010·Cardiovascular Diabetology·Enrique Z Fisman, Alexander Tenenbaum
Feb 26, 2011·Journal of Applied Physiology·Mette Bisgaard AndersenHenning Langberg

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Citations

Jun 16, 2014·Sports Medicine·Femke M A P ClaessenDuncan E Meuffels
Feb 13, 2014·Arthritis Research & Therapy·Hayedeh BehzadAlex Scott
Mar 27, 2013·Current Medical Research and Opinion·Bernd WolfarthCathy Speed
Mar 13, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nelly Andarawis-PuriLouis J Soslowsky
Jul 11, 2013·International Journal of Experimental Pathology·Karen McCreesh, Jeremy Lewis
Feb 3, 2015·Scandinavian Journal of Medicine & Science in Sports·C T ThorpeH R C Screen
Apr 19, 2015·Arthritis Research & Therapy·Mandy Jayne PeffersHelen Lucy Birch
Aug 26, 2014·Rheumatology·Rouhollah MousavizadehAlex Scott
Feb 12, 2015·Clinical Orthopaedics and Related Research·Isabel AndiaNicola Maffulli
Mar 12, 2013·British Journal of Sports Medicine·Jonathan D ReesAlex Scott
Sep 16, 2016·Omics : a Journal of Integrative Biology·Masouda RahimAlison V September
Nov 21, 2014·Foot & Ankle International·Mary Claire ManskeSandra E Klein
Mar 22, 2016·Acta ortopedica brasileira·Luiz Henrique Oliveira AlmeidaJoel Murachovsky
Sep 30, 2016·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Adham do Amaral E CastroWagner Haese Barros
Jan 26, 2017·Nature Reviews. Rheumatology·Neal L MillarIain B McInnes
Feb 2, 2018·International Journal of Molecular Sciences·Franka Klatte-SchulzBritt Wildemann
May 2, 2018·The Journal of Orthopaedic and Sports Physical Therapy·Robroy L MartinChristopher R Carcia
Jan 15, 2019·The American Journal of Sports Medicine·Kandir Genesio Innocenti DinhaneWinston Bonetti Yoshida
Mar 1, 2019·Annals of the New York Academy of Sciences·Jiewen LiCatherine K Kuo
Dec 16, 2019·British Medical Bulletin·Emanuele ChisariNicola Maffulli
Jan 15, 2020·Connective Tissue Research·Stefania L WunderliJess G Snedeker
Feb 8, 2020·BMC Musculoskeletal Disorders·George JomaaChrister Rolf
May 24, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Solaiman TarafderChang H Lee
Jan 21, 2017·Scandinavian Journal of Medicine & Science in Sports·P P Y Lui
Dec 6, 2017·Bone & Joint Research·W MoritaA J Carr
Mar 1, 2019·Science Translational Medicine·Adam C AbrahamStavros Thomopoulos
Feb 26, 2020·BMC Biomedical Engineering·Sophia K Theodossiou, Nathan R Schiele
Jun 10, 2020·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Mark F ZhuJacob T Munro
Aug 31, 2017·Scientific Reports·Meaghan StolkMartina Seifert
Apr 30, 2017·Clinical Orthopaedics and Related Research·Emmanuel C EkwuemeJoseph W Freeman
Oct 10, 2020·World Journal of Stem Cells·Hao-Nan WangGuo-Xin Ni
Mar 11, 2021·Journal of the American Podiatric Medical Association·Chad C CarrollDonald Curtis
Apr 4, 2021·International Journal of Molecular Sciences·Sandeep SilawalGundula Schulze-Tanzil

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Methods Mentioned

BETA
Assay
PCR

Software Mentioned

Primer Express
PrimerDesign
SPSS

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