Increased expression of integrins by heparin-binding EGF like growth factor in human esophageal cancer cells

Cancer Letters
M SatoR Kannagi

Abstract

The adhesion of cancer cells to vascular endothelium is an important step in the hematogenous metastasis of cancer. The authors investigated the alteration of integrin expression in human esophageal cancer cells, following the selectin-mediated initial adhesion to endothelial cells. The expression of alpha2 beta1 and alpha3 beta1 integrins in esophageal cancer cells (TE-1 and T.Tn), strongly expressing EGF-receptors, were markedly increased by the addition of the heparin-binding EGF like growth factor (HB-EGF). The increase of integrin expression in esophageal cancer cells was inhibited by the addition of the tyrosine kinase inhibitor, genistein. HB-EGF treatment of esophageal cancer cells resulted in the augmentation of cancer cell adhesion to immobilized collagen. When esophageal cancer cells were co-cultured with endothelial cells, similar levels of augmentation of cancer cell adhesion to collagen were observed. The augmentation of cancer cell adhesion to collagen was inhibited by the addition of anti-HB-EGF neutralizing antibody. Our interpretation of the results described above is that the cancer cells receive stimulation from cytokines, such as HB-EGF, produced by endothelial cells, following initial adhesion of cancer ce...Continue Reading

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Citations

Mar 5, 1998·Journal of Surgical Oncology·J HosonoR Kannagi
Feb 24, 2000·The Journal of Pathology·F W OrrD M Nance
Feb 13, 2003·Molecular and Cellular Endocrinology·Xiaoli Shen, Miriam Falzon
Mar 26, 2005·Journal of Clinical Pathology·K S NairR Chetty
Sep 15, 2017·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·N KarthirajAshwin K Mani
Oct 27, 2007·The Oncologist·Simon EkmanJohan Lennartsson
May 1, 1999·The Journal of Nutrition·D LiL Yan
Aug 4, 2004·Cancer Research·Pat P OngusahaSam W Lee

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