Increased expression of interleukin-23 p19 mRNA in erythema nodosum-like lesions of Behçet's disease

The British Journal of Dermatology
W LewD Bang

Abstract

Behçet's disease (BD) is a multisystemic chronic inflammatory disease with unknown aetiology. Interleukin (IL)-12, which is involved in the pathogenesis of BD, is a 70-kDa cytokine made of p35 and p40 subunits. Recently, IL-23, which is composed of a p19 subunit and a shared p40 subunit of IL-12, was discovered; as a consequence, this raises the need to re-examine previous IL-12 reports to determine whether IL-23 is also involved in BD pathogenesis. To determine whether there are changes in IL-23 in skin lesions and sera of patients with BD. For quantitative reverse transcription-polymerase chain reaction, the total cellular RNA of erythema nodosum (EN)-like skin lesions from patients with BD, psoriasis skin lesions and skin biopsy samples from normal individuals was analysed. To determine cytokine levels, sera from patients with BD and normal individuals were analysed. Increased IL-23 p19 mRNA levels were observed for both EN-like lesions of patients with BD and skin lesions of patients with psoriasis compared with normal individuals. Although we observed an elevation of IL-12/23 p40 mRNA expression in the BD lesions, this was not significant. Moreover, the levels of IL-12 p35 mRNA in BD lesions were also not significantly dif...Continue Reading

References

Aug 23, 1979·The New England Journal of Medicine·D G James
Oct 1, 1989·Journal of Cutaneous Pathology·S I ChunR S Rogers
Oct 1, 1996·Genome Research·C A HeidP M Williams
Mar 31, 1998·Journal of Immunological Methods·N KruseP Rieckmann
Apr 16, 1998·The Journal of Investigative Dermatology·F van RuissenJ Schalkwijk
Oct 9, 2002·Scandinavian Journal of Rheumatology·Kamel HamzaouiKhaled Ayed
Aug 21, 2003·The Journal of Dermatology·Buket Cicioglu AridoganSelcuk Kaya
Dec 10, 2003·The Journal of Experimental Medicine·Craig A MurphyDaniel J Cua
Jan 7, 2004·The Journal of Experimental Medicine·Edmund LeeJames G Krueger
Jan 19, 2005·Clinical and Experimental Immunology·Y ImamuraN Suzuki
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
Jan 25, 2005·Clinical and Experimental Dermatology·M O OztasB Sancak
Feb 23, 2005·Journal of Dental Research·L M Al-OtaibiT W J Poate
Aug 17, 2005·International Journal of Dermatology·Güneş Gür-ToyNuran Alli
Sep 1, 2005·Rheumatology International·Huseyin T E OzerOguz Kara
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gamze PiskinMarcel B M Teunissen
May 4, 2006·The Journal of Clinical Investigation·David YenDonna Rennick

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Citations

Dec 17, 2009·Archives of Dermatological Research·Alexandra VarolChris D Anderson
Jul 14, 2010·Clinical Rheumatology·Rui-Xue LengDong-Qing Ye
Nov 6, 2010·Clinical & Developmental Immunology·Fumio KanekoKeiji Oguma
Feb 26, 2011·American Journal of Clinical Dermatology·Marta KurzejaMalgorzata Olszewska
Dec 12, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·S ChoD Bang
Jul 4, 2012·Journal of Biomedicine & Biotechnology·Pascale QuatresoozClaudine Piérard-Franchimont
Jun 28, 2016·Pharmacogenomics·Tamer A GheitaSanaa A Kenawy
Dec 22, 2011·Yonsei Medical Journal·Sung Bin ChoDongsik Bang
Aug 27, 2014·Clinical and Experimental Dermatology·B YalçinS Dogan
May 10, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·S ChoD Bang
Jul 30, 2017·Journal of Clinical Medicine·Yuki NankeShigeru Kotake
Nov 9, 2019·International Journal of Rheumatic Diseases·Changlong GuoXu Ma

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