Increased expression of laminin-5 and its prognostic significance in hypopharyngeal cancer

The Laryngoscope
Meijin NakayamaS Hirohashi

Abstract

We investigated the clinicopathologic significance of laminin-5 gamma2 chain (LNgamma2) expression in 26 surgically removed hypopharyngeal cancers and compared the results with conventional prognostic factors elicited from hematoxylin-eosin (H&E) stained whole-mount laryngeal sections. Stainability of LNgamma2 was mainly evaluated at the invasive front of the cancer nests. Scoring was performed on the basis of a semiquantitative scale defined according to the number of immunopositive cancer cells (score 3, 2, 1, and 0). Stainability of LNgamma2 was also evaluated macroscopically at different tumor locations such as surface center, interstitial space, and invasive front. Status of cartilage and vascular invasion and patterns of tumor extension were evaluated from H&E stained sections. The results of LNgamma2 expression correlated with the tumor stages, neck node status, pathologic differentiation, and prognoses. Among the 26 cases, 24 demonstrated positive LNgamma2 expression. Of these cases, 1, 14, 9, and 0 showed scores of 3, 2, 1, and 0, respectively. Positive expression of LNgamma2 at the invasive front was more prominent in the high-expression group, and surface center was often positive in the cases of low-expression group...Continue Reading

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Citations

Jun 1, 2011·Journal of the American Academy of Dermatology·Wing Yan Yuen, Marcel F Jonkman
Aug 19, 2009·Matrix Biology : Journal of the International Society for Matrix Biology·Cherise M Guess, Vito Quaranta
May 2, 2006·Head & Neck·Amy F ZioberBarry L Ziober
May 1, 2021·Cancers·Nathalia Meireles Da CostaAntonio Palumbo Júnior

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