Increased Expression of LIPC Is Associated with Aggressive Phenotype of Borrmann Type 4 Gastric Cancer.

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Jin-Yu HuangHui-Mian Xu

Abstract

To investigate lipase C hepatic type (LIPC) expression in Borrmann type 4 gastric cancer and its correlation with clinical outcome. The biological roles of LIPC in Borrmann type 4 gastric cancer progression were also investigated. We determined LIPC expression in 324 primary gastric cancer tissues and 178 matched adjacent non-tumor tissues by immunohistochemistry. We explored the role of LIPC in Borrmann type 4 gastric cancer cell (OCUM-1) migration, invasion, proliferation, cell cycle, and expression of epithelial-mesenchymal transition-related genes by knocking down LIPC expression. LIPC expression was upregulated in Borrmann type 4 gastric cancer tissues compared with other types of gastric cancer and adjacent non-tumor tissues. High LIPC expression correlated with lymph node metastasis, advanced TNM stage, and poor overall survival in Borrmann type 4 gastric cancer patients. Multivariate analysis demonstrated that high LIPC expression was an independent prognostic factor in patients with Borrmann type 4 gastric cancer. By reducing LIPC expression, OCUM-1 cell invasion and migration were suppressed and Snail and MMP2 expression was downregulated, while E-cadherin expression was upregulated. High LIPC expression correlates wi...Continue Reading

References

May 18, 2007·Nature Reviews. Cancer·Héctor PeinadoAmparo Cano
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
May 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
Jan 25, 2013·Cell Cycle·Lorenzo GalluzziGuido Kroemer
Jul 22, 2015·Journal of Atherosclerosis and Thrombosis·Junji KobayashiHiroshi Mabuchi
Dec 17, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lindsey A TorreAhmedin Jemal
Feb 18, 2016·The FEBS Journal·Barrie Peck, Almut Schulze
Feb 26, 2016·World Journal of Surgical Oncology·Yifan LuoZhenning Wang
Jul 2, 2016·The Journal of Surgical Research·Jin-Yu HuangYing-Ying Xu
Nov 5, 2016·Annals of the Royal College of Surgeons of England·R J ThompsonJ A Kennedy
Oct 4, 2017·The FEBS Journal·Upasana Ray, Sib Sankar Roy
Dec 6, 2017·Trends in Endocrinology and Metabolism : TEM·Thomas W Grunt
Mar 17, 2018·Nature Reviews. Cancer·Christina H StueltenDenise J Montell
Dec 13, 2018·Cellular and Molecular Life Sciences : CMLS·Prakash P PraharajSujit Kumar Bhutia
Dec 31, 2018·Trends in Cell Biology·Ievgenia Pastushenko, Cédric Blanpain
Jan 4, 2019·Nature Cell Biology·Marc P StemmlerThomas Brabletz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.