Increased expression of miR-33a in monocytes from Mexican hypertensive patients in elevated carotid intima-media thickness

Journal of Human Hypertension
Yazmín Estela Torres-PazRicardo Gamboa

Abstract

miR-33a has been described as a key regulator in the initiation and progression of atherosclerosis. However, its role in arterial hypertension (HTA) has not been elucidated. Therefore, the aim of this study was to determine the association between the expression of miR-33a (5p and 3p) and the carotid intima-media thickness (cIMT) in samples of monocytes and serum from hypertensive patients. The miR-33a-5p and miR-33a-3p expression in monocytes and serum from Mexican hypertensive patients were examined by RT-PCR. This study involved 84 subjects (42 normotensive subjects and 42 patients with essential hypertension). Our study revealed that miR-33a-5p expression was significantly upregulated in the monocytes of hypertensive patients compared with the control group (p = 0.001), while miR-33a-3p was significantly downregulated (p = 0.013). miR-33a-5p upregulation [OR: 5.53, 95% CI: 2.01-15.20; p = 0.001], as well as miR-33a-3p downregulation [OR: 3.32, 95% CI: 1.45-7.60; p = 0.004] in monocytes, was associated with an increased risk of developing hypertension. In addition, miR-33a-5p upregulation in hypertensive patients was associated with an increased risk of presenting cIMT [OR: 5.99, 95% CI: 1.10-32.85; p = 0.039]. Moreover, we ...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 13, 2003·Atherosclerosis·Peggy RobinetJean Louis Paul
Oct 22, 2003·Cell·Dianne S SchwarzPhillip D Zamore
Oct 22, 2003·Cell·Anastasia KhvorovaSumedha D Jayasena
Aug 30, 2007·Nucleic Acids Research·Seungil RoWei Yan
Feb 12, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·James H SteinUNKNOWN American Society of Echocardiography Carotid Intima-Media Thickness Task Force
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Jan 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amy N PackerBeverly L Davidson
Jun 19, 2010·Science·Michael S BrownJoseph L Goldstein
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tyler J MarquartAngel Baldán
Sep 18, 2010·Clinical Chemistry·Jessica A WeberKai Wang
Jun 8, 2011·The Journal of Clinical Investigation·Katey J RaynerKathryn J Moore
Jan 26, 2012·Thrombosis and Haemostasis·K J RaynerK J Moore
Dec 25, 2012·Atherosclerosis·Wu-Jun ChenChao-Ke Tang
Jul 5, 2013·American Journal of Respiratory and Critical Care Medicine·Yongguang XiaoHanzhong Liu
Jun 18, 2014·International Journal of Medical Sciences·Chiu-Jung HuangTunku Kamarul
Oct 8, 2014·Journal of Biomedical Science·Kong Bung ChooChiu-Jung Huang
Jun 19, 2015·International Heart Journal·Koh OnoTakeshi Kimura
Dec 10, 2015·Journal of cardiology·Koh Ono
Dec 15, 2015·Advances in Experimental Medicine and Biology·Jan NovákGaetano Santulli
Jun 17, 2016·Scientific Reports·Kuo-Wang TsaiHong-Tai Chang

❮ Previous
Next ❯

Citations

Sep 21, 2018·Journal of Human Hypertension·Durairaj Sekar

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
lipidation

Software Mentioned

mirPath
cIMT
TargetScan Human
miRTar

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.