Abstract
miR-33a has been described as a key regulator in the initiation and progression of atherosclerosis. However, its role in arterial hypertension (HTA) has not been elucidated. Therefore, the aim of this study was to determine the association between the expression of miR-33a (5p and 3p) and the carotid intima-media thickness (cIMT) in samples of monocytes and serum from hypertensive patients. The miR-33a-5p and miR-33a-3p expression in monocytes and serum from Mexican hypertensive patients were examined by RT-PCR. This study involved 84 subjects (42 normotensive subjects and 42 patients with essential hypertension). Our study revealed that miR-33a-5p expression was significantly upregulated in the monocytes of hypertensive patients compared with the control group (p = 0.001), while miR-33a-3p was significantly downregulated (p = 0.013). miR-33a-5p upregulation [OR: 5.53, 95% CI: 2.01-15.20; p = 0.001], as well as miR-33a-3p downregulation [OR: 3.32, 95% CI: 1.45-7.60; p = 0.004] in monocytes, was associated with an increased risk of developing hypertension. In addition, miR-33a-5p upregulation in hypertensive patients was associated with an increased risk of presenting cIMT [OR: 5.99, 95% CI: 1.10-32.85; p = 0.039]. Moreover, we ...Continue Reading
References
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 13, 2003·Atherosclerosis·Peggy RobinetJean Louis Paul
Oct 22, 2003·Cell·Dianne S SchwarzPhillip D Zamore
Oct 22, 2003·Cell·Anastasia KhvorovaSumedha D Jayasena
Mar 23, 2007·Cardiovascular Research·Vicenta Llorente-CortésLina Badimon
Aug 30, 2007·Nucleic Acids Research·Seungil RoWei Yan
Feb 12, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·James H SteinUNKNOWN American Society of Echocardiography Carotid Intima-Media Thickness Task Force
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Jan 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amy N PackerBeverly L Davidson
Jan 22, 2010·BMC Genomics·Guru JagadeeswaranRamanjulu Sunkar
May 27, 2010·Cancer Research·Francesca FornariLaura Gramantieri
Jun 19, 2010·Science·Michael S BrownJoseph L Goldstein
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tyler J MarquartAngel Baldán
Sep 18, 2010·Clinical Chemistry·Jessica A WeberKai Wang
Mar 18, 2011·Revista española de cardiología·Irene MateoVicente Bertomeu-Martínez
Jun 8, 2011·The Journal of Clinical Investigation·Katey J RaynerKathryn J Moore
Oct 21, 2011·Nature·Katey J RaynerKathryn J Moore
Jan 26, 2012·Thrombosis and Haemostasis·K J RaynerK J Moore
Dec 25, 2012·Atherosclerosis·Wu-Jun ChenChao-Ke Tang
Jan 15, 2013·Atherosclerosis·P CostalesV Llorente-Cortés
Jul 5, 2013·American Journal of Respiratory and Critical Care Medicine·Yongguang XiaoHanzhong Liu
Oct 8, 2013·Annals of Surgery·A Yaël NossentSøren P Sheikh
Jun 18, 2014·International Journal of Medical Sciences·Chiu-Jung HuangTunku Kamarul
Oct 8, 2014·Journal of Biomedical Science·Kong Bung ChooChiu-Jung Huang
Jun 19, 2015·International Heart Journal·Koh OnoTakeshi Kimura
Dec 10, 2015·Journal of cardiology·Koh Ono
Dec 15, 2015·Advances in Experimental Medicine and Biology·Jan NovákGaetano Santulli
Jun 17, 2016·Scientific Reports·Kuo-Wang TsaiHong-Tai Chang
Sep 16, 2016·Journal of Atherosclerosis and Thrombosis·Jing DongYu-Xiang Yan