Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas

Virchows Archiv : an International Journal of Pathology
Céline PinheiroFátima Baltazar

Abstract

Tumour cells are known to be highly glycolytic, thus producing high amounts of lactic acid. Monocarboxylate transporters (MCTs), by promoting the efflux of the accumulating acids, constitute one of the most important mechanisms in the maintenance of tumour intracellular pH. Since data concerning MCT expression in colorectal carcinomas (CRC) are scarce and controversial, the present study aimed to assess the expressions of MCT1, 2, and 4 in a well characterized series of CRC and assess their role in CRC carcinogenesis. CRC samples (126 cases) were analyzed for MCT1, MCT2, and MCT4 immunoexpression and findings correlated with clinico-pathological parameters. Expression of all MCT isoforms in tumour cells was significantly increased when compared to adjacent normal epithelium. Remarkably, there was a significant gain of membrane expression for MCT1 and MCT4 and loss of plasma membrane expression for MCT2 in tumour cells. Plasma membrane expression of MCT1 was directly related to the presence of vascular invasion. This is the larger study on MCT expression in CRC and evaluates for the first time its clinico-pathological significance. The increased expression of these transporters suggests an important role in CRC, which might just...Continue Reading

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Citations

Jan 10, 2012·International Journal of Colorectal Disease·Claudio CacchiB Märkl
Mar 13, 2012·Journal of Bioenergetics and Biomembranes·Céline PinheiroFátima Baltazar
Dec 23, 2011·Bulletin of Mathematical Biology·Berta Mendoza-JuezVíctor M Pérez-García
Jul 17, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Maolan LiYingbin Liu
Jun 9, 2012·The British Journal of Nutrition·Kim Y C FungDavid L Topping
Aug 13, 2011·Nature Reviews. Cancer·Bradley A WebbDiane L Barber
Dec 22, 2012·Neuro-oncology·Vera Miranda-GonçalvesFátima Baltazar
Aug 30, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Céline PinheiroFátima Baltazar
Dec 17, 2008·American Journal of Physiology. Cell Physiology·Shannon M GallagherNancy J Philp
Nov 27, 2008·The Journal of Clinical Investigation·Pierre SonveauxMark W Dewhirst
Sep 4, 2013·The Journal of Clinical Investigation·Joanne R Doherty, John L Cleveland
Jul 30, 2014·World Journal of Gastroenterology : WJG·Feng TaoWei Wang
Jan 16, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong WangConggang Hu
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May 11, 2010·Journal of Biomedicine & Biotechnology·Céline PinheiroFátima Baltazar
Oct 9, 2015·BioMed Research International·Sandra F MartinsAdhemar Longatto-Filho
Jul 25, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Céline PinheiroFátima Baltazar
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Dec 8, 2015·Journal of Experimental & Clinical Cancer Research : CR·Shuiying ZhaoGuijun Qin
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May 14, 2011·The FEBS Journal·Anique HerlingHermann-Georg Holzhütter
May 24, 2012·Diagnostic Cytopathology·Céline PinheiroFátima Baltazar
Jul 20, 2010·Histopathology·Céline PinheiroFátima Baltazar
Dec 3, 2014·Biochimica Et Biophysica Acta·Enrico Pierluigi SpugniniStefano Fais

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