Increased expression of placenta growth factor in COPD.

Thorax
S-L ChengP-C Yang

Abstract

Vascular endothelial growth factor (VEGF) and its receptor may have an important role in the pathogenesis of emphysema. The effect of another angiogenic factor, placenta growth factor (PlGF), in chronic obstructive pulmonary disease (COPD) is unknown. The serum levels of VEGF and PlGF in patients with COPD (n = 184), smokers (n = 212) and non-smokers (n = 159) and the bronchoalveolar lavage (BAL) fluid levels of VEGF and PlGF in another group (20 patients with COPD, 18 controls) were measured. In vitro cell culture experiments were performed to investigate the effect of PlGF on VEGF. The mean (SE) serum levels of PlGF were significantly higher in patients with COPD than in controls (27.1 (7.4) pg/ml vs 12.3 (5.1) pg/ml in smokers and 10.8 (6.3) pg/ml in non-smokers, p = 0.005). The levels of PlGF in BAL fluid were also significantly higher in patients with COPD than in controls (45.7 (12.3) pg/ml vs 23.9 (7.6) pg/ml, p = 0.005), associated with an increase in the cytokines tumour necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8). In patients with COPD the levels of PlGF correlated inversely with forced expiratory volume in 1 s (FEV(1)) in serum (r = -0.59, p = 0.002) and in BAL fluid (r = -0.51, p = 0.001). While the s...Continue Reading

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Citations

Nov 26, 2009·Respiratory Research·Shih Lung ChengPan Chyr Yang
Jan 27, 2011·Respiratory Research·Michelle SandsPaul McLoughlin
Jan 24, 2012·American Journal of Respiratory Cell and Molecular Biology·Sonja BobicPeter W Hellings
Jun 29, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Shernan G Holtan, Mukta Arora
Sep 5, 2014·Respiratory Research·Hsin-Han HouChong-Jen Yu
Dec 17, 2009·The Journal of Pediatrics·Anne R HansenThomas F McElrath
Dec 23, 2015·The Journal of Clinical Investigation·Marthe-Sandrine Eiymo Mwa MpolloPunam Malik
Dec 18, 2014·Cell Biochemistry and Function·Liang ZhangXin-Dong Xue
Sep 5, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Cui MaDaling Zhu
May 4, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hsin-Han HouChong-Jen Yu
Nov 19, 2009·Growth Factors·Mikael MikkoC Magnus Sköld

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Methods Mentioned

BETA
bronchoalveolar lavage
enzyme-linked immunosorbent assay
ELISA
electrophoresis
light microscopy

Software Mentioned

SPSS

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