Abstract
Vascular endothelial growth factor (VEGF) and its receptor may have an important role in the pathogenesis of emphysema. The effect of another angiogenic factor, placenta growth factor (PlGF), in chronic obstructive pulmonary disease (COPD) is unknown. The serum levels of VEGF and PlGF in patients with COPD (n = 184), smokers (n = 212) and non-smokers (n = 159) and the bronchoalveolar lavage (BAL) fluid levels of VEGF and PlGF in another group (20 patients with COPD, 18 controls) were measured. In vitro cell culture experiments were performed to investigate the effect of PlGF on VEGF. The mean (SE) serum levels of PlGF were significantly higher in patients with COPD than in controls (27.1 (7.4) pg/ml vs 12.3 (5.1) pg/ml in smokers and 10.8 (6.3) pg/ml in non-smokers, p = 0.005). The levels of PlGF in BAL fluid were also significantly higher in patients with COPD than in controls (45.7 (12.3) pg/ml vs 23.9 (7.6) pg/ml, p = 0.005), associated with an increase in the cytokines tumour necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8). In patients with COPD the levels of PlGF correlated inversely with forced expiratory volume in 1 s (FEV(1)) in serum (r = -0.59, p = 0.002) and in BAL fluid (r = -0.51, p = 0.001). While the s...Continue Reading
References
Jul 1, 1992·Internal Medicine·H KanazawaT Takeda
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D MaglioneM G Persico
Mar 1, 1994·Human Molecular Genetics·C HassettC J Omiecinski
Jan 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·T DiPalmaM G Persico
Dec 17, 1998·American Journal of Obstetrics and Gynecology·D S TorryR J Torry
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·Y KasaharaN F Voelkel
May 1, 2001·Nature Medicine·P CarmelietM G Persico
Oct 24, 2002·The European Respiratory Journal. Supplement·K F Chung
Apr 26, 2003·The American Journal of Medicine·Hiroshi KanazawaJunichi Yoshikawa
Jul 3, 2003·The Journal of Biological Chemistry·Lior ZilberbergAndreas Bikfalvi
Dec 3, 2003·American Journal of Respiratory and Critical Care Medicine·Po-Nien TsaoSu-Ming Hsu
Jun 29, 2004·The European Respiratory Journal·B R CelliUNKNOWN ATS/ERS Task Force
Feb 1, 2005·Thorax·A R KranenburgH S Sharma
Nov 24, 2005·Chest·Hiroshi Kanazawa, Junichi Yoshikawa
Dec 20, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·John A MarwickPaul A Kirkham
Mar 9, 2007·Respiratory Research·Hiroshi KanazawaSaeko Nomura
Citations
Sep 7, 2013·Cell Death & Disease·H H HouC J Yu
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·J SauledaA G Agustí
Nov 26, 2009·Respiratory Research·Shih Lung ChengPan Chyr Yang
Jan 27, 2011·Respiratory Research·Michelle SandsPaul McLoughlin
Sep 8, 2011·BMC Pulmonary Medicine·Jeroen D LangereisLaurien H Ulfman
Oct 4, 2011·BMC Pulmonary Medicine·Shih-Lung ChengChong-Jen Yu
Jan 24, 2012·American Journal of Respiratory Cell and Molecular Biology·Sonja BobicPeter W Hellings
Jun 29, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Shernan G Holtan, Mukta Arora
Dec 5, 2014·Chest·Anne Sophie GamezArnaud Bourdin
Jan 17, 2012·Oral Oncology·Shih-Jung ChengChun-Pin Chiang
Sep 5, 2014·Respiratory Research·Hsin-Han HouChong-Jen Yu
Dec 17, 2009·The Journal of Pediatrics·Anne R HansenThomas F McElrath
Dec 23, 2015·The Journal of Clinical Investigation·Marthe-Sandrine Eiymo Mwa MpolloPunam Malik
Mar 31, 2009·Archivos de bronconeumología·Nuria Somoza, Montserrat Torà
Oct 17, 2013·Allergy·S BobicP W Hellings
Dec 18, 2014·Cell Biochemistry and Function·Liang ZhangXin-Dong Xue
Sep 5, 2015·Respiratory Research·B R LeakerP J Barnes
Sep 5, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Cui MaDaling Zhu
Jul 6, 2014·Autophagy·Hsin-Han HouChong-Jen Yu
Aug 30, 2011·Cytokine·Jeroen D LangereisLeo Koenderman
Nov 24, 2016·Scientific Reports·Chou-Han LinLi-Na Lee
Feb 22, 2017·Scientific Reports·Dong WuBin Wu
May 4, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hsin-Han HouChong-Jen Yu
Nov 19, 2009·Growth Factors·Mikael MikkoC Magnus Sköld
Aug 9, 2019·Therapeutic Advances in Respiratory Disease·Yang YaoShengyu Wang
Mar 1, 2008·Clinical Science·Arschang ValipourOtto Chris Burghuber