Increased expression of ras genes in non-Hodgkin's lymphomas is not associated with oncogenic activation of those genes by point mutation

Japanese Journal of Cancer Research : Gann
K HamataniH Shiku

Abstract

Twenty-three cases of non-Hodgkin's lymphoma (NHL) were analyzed for expression of ras genes by in situ hybridization utilizing biotinylated DNA probes. Increased expression of Ki-ras, Ha-ras and N-ras genes was observed in 12 cases, 6 cases and 1 case of NHL, respectively. Genomic DNA extracted from these 23 cases of NHL was region-specifically amplified by means of polymerase chain reaction to examine the presence of point mutations at the 12th, 13th and 61st codons of Ki-, Ha- and N-ras genes. Dot hybridization assays with appropriate oligonucleotide probes showed no evidence of point mutation in any case of NHL examined. These results indicate that increased expression of ras genes in NHL is not associated with ras gene activation by point mutation.

References

Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A NeriR Dalla-Favera
Jan 15, 1988·International Journal of Cancer. Journal International Du Cancer·H P SennC Moroni
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C J FarrC J Marshall
May 1, 1988·Mutation Research·J L Bos
Jan 1, 1987·Annual Review of Biochemistry·M Barbacid
May 3, 1987·Nature·J L BosB Vogelstein

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Citations

Jan 1, 1993·Toxicologic Pathology·M D EdwardsB R Madewell
Jan 1, 1990·Japanese Journal of Cancer Research : Gann·Y NagataH Shiku
Feb 1, 1993·Japanese Journal of Cancer Research : Gann·M KoshibaT Sugiyama
Jan 1, 1990·Molecular Carcinogenesis·S J Garte
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D M Beaupre, R Kurzrock

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