Increased expression of regulatory T cells and down-regulatory molecules in lepromatous leprosy.

The American Journal of Tropical Medicine and Hygiene
Maria L PalermoGil Benard

Abstract

T regulatory cells (Tregs) play an important role in the mechanism of host's failure to control pathogen dissemination in severe forms of different chronic granulomatous diseases, but their role in leprosy has not yet been elucidated; 28 newly diagnosed patients (16 patients with lepromatous leprosy and 12 patients with tuberculoid leprosy) and 6 healthy Mycobacterium leprae-exposed individuals (contacts) were studied. Tregs were quantified by flow cytometry (CD4+ CD25+ Foxp3+) in peripheral blood mononuclear cells stimulated in vitro with a M. leprae antigenic preparation and phytohemagglutinin as well as in skin lesions by immunohistochemistry. The lymphoproliferative (LPR), interleukin-10 (IL-10), and interferon-γ (IFN-γ) responses of the in vitro-stimulated peripheral blood mononuclear cells and the in situ expression of IL-10, transforming growth factor-β (TGF-β), and cytotoxic T-lymphocyte antigen 4 (CTLA-4) were also determined. We show that M. leprae antigens induced significantly lower LPR but significantly higher Treg numbers in lepromatous than tuberculoid patients and contacts. Mitogen-induced LPR and Treg frequencies were not significantly different among the three groups. Tregs were also more frequent in situ in l...Continue Reading

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Citations

Apr 12, 2014·PLoS Neglected Tropical Diseases·Kidist BoboshaAnnemieke Geluk
Dec 18, 2013·Future Microbiology·Yang DegangKoichi Suzuki
Nov 30, 2014·Clinics in Dermatology·Indira NathVijaya Lakshmi Valluri
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Jan 7, 2016·BMC Research Notes·Huma AftabIb C Bygbjerg
Aug 17, 2014·Microbial Pathogenesis·Juarez Antonio Simões QuaresmaHellen Thais Fuzii
Sep 12, 2014·PLoS Neglected Tropical Diseases·Deanna A HaggeLinda B Adams
Jan 12, 2016·PLoS Neglected Tropical Diseases·Soumi SadhuDipendra Kumar Mitra
Feb 13, 2015·Anais Brasileiros De Dermatologia·José Napoleão Tavares ParenteCesare Massone
Feb 24, 2016·The American Journal of Tropical Medicine and Hygiene·Ana Paula VieiraGil Benard
Feb 7, 2017·Infectious Diseases of Poverty·Adriana Barbosa de Lima FonsecaAmelia Ribeiro de Jesus
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Sep 10, 2018·Microbial Pathogenesis·Jairo Campos de CarvalhoMárcio Sobreira Silva Araújo
Nov 9, 2021·PLoS Neglected Tropical Diseases·Marília Brasil XavierCarlos Eduardo Pereira Corbett

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