Increased expression of Slit2 and its receptors Robo1 and Robo4 in reactive astrocytes of the rat hippocampus after transient forebrain ischemia

Brain Research
Joo-Hee ParkMun-Yong Lee

Abstract

Slit2 is a secreted glycoprotein that was originally identified as a chemorepulsive factor in the developing brain; however, it was recently reported that Slit2 is associated with adult neuronal function including a variety of pathophysiological processes. To elucidate whether Slit2 is implicated in the pathophysiology of ischemic injury, we investigated the temporal changes and cellular localization of Slit2 and its predominant receptors, Robo1 and Robo4, for 28 days after transient forebrain ischemia. Slit2 and its receptors had similar overall expression patterns in the control and ischemic hippocampi. The ligand and receptors were constitutively expressed in hippocampal neurons in control animals; however, in animals with ischemic injury, their upregulation was detected in reactive astrocytes, but not in neurons or activated microglia, in the CA1 region. Astroglial induction of Slit2 and its receptors occurred by day 3 after reperfusion, and appeared to increase progressively until the final time point on day 28. Their temporal expression patterns overlapped with the time period in which reactive astrocytes undergo dynamic structural changes and appear hypertrophic in the ischemic hippocampus. The immunohistochemical data w...Continue Reading

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Citations

May 8, 2020·Expert Opinion on Therapeutic Targets·Prativa SherchanJohn H Zhang
Aug 8, 2018·International Journal of Molecular Medicine·Ge LiYu Zhang
Jun 21, 2018·Frontiers in Pediatrics·Antonio Benítez-BurracoMa Salud Jiménez-Romero
Aug 6, 2021·Frontiers in Cell and Developmental Biology·Sara A KirolosRichard H Gomer

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