Increased expression of specific recognition molecules by retinal ganglion cells and by optic pathway glia accompanies the successful regeneration of retinal axons in adult zebrafish

The Journal of Comparative Neurology
R R BernhardtMelitta Schachner

Abstract

Retinal ganglion cells (RGCs) in adult zebrafish can regenerate their axons. We show that successful axonal regeneration is accompanied by the re-expression by RGCs of mRNAs encoding specific recognition molecules that are expressed at high levels in the larval retina but are down-regulated in the adult. Message levels for 11.1 and 11.2 (two homologs of mammalian L1), n-cam (homologous to mammalian N-CAM), beta 3 (related to the beta 3 and beta 2 subunits of mammalian Na,K-ATPase), and tn-c (homologous to mammalian tenascin-C) were high in larval RGCs undergoing axonogenesis and low in adult RGCs. After an optic nerve crush, axotomized adult RGCs showed increased levels of 11.1, 11.2 and n-cam mRNA expression, whereas the levels of beta 3 and tn-cmRNA remained unchanged. The optic nerve crush also induced the expression of some of these mRNAs in the optic nerve and tract where they are not normally detectable. This lesion induced up-regulation by presumptive glia was observed for 11.1, 11.2, n-cam and beta 3 but not for tn-c. The combination of a neuronal (intrinsic) response to axotomy with an environmental (extrinsic) response may be an important determinant allowing for the successful axonal regeneration.

References

Dec 1, 1977·The Journal of Comparative Neurology·P R Johns
Jan 1, 1992·Trends in Neurosciences·J W Fawcett
Oct 1, 1992·Genes & Development·Y SagaS Aizawa
Jul 1, 1992·Journal of Neurobiology·C A StuermerK Paschke
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A G WattsR Levenson
Jan 1, 1990·The Journal of Cell Biology·S GloorM Schachner
Dec 15, 1990·The Journal of Comparative Neurology·R R BernhardtJ Y Kuwada
Jan 1, 1991·Annual Review of Neuroscience·L F Reichardt, K J Tomaselli
Mar 1, 1990·Developmental Biology·J Drazba, V Lemmon
Jan 1, 1989·Annual Review of Cell Biology·H P Erickson, M A Bourdon
Jun 1, 1989·The Journal of Comparative Neurology·R Bernhardt
Dec 1, 1988·Developmental Biology·L LandmesserU Rutishauser
Nov 1, 1994·Trends in Neurosciences·M Bähr, F Bonhoeffer
Jan 1, 1993·Annual Review of Neuroscience·M E SchwabC E Bandtlow
Aug 22, 1994·The Journal of Comparative Neurology·J D Burrill, S S Easter
Feb 1, 1994·Current Opinion in Neurobiology·P Doherty, F S Walsh
Nov 1, 1995·Journal of Neuroscience Research·E TongiorgiM Schachner
Jan 1, 1990·The European Journal of Neuroscience·S. R. PagliusiB. D. Shivers

❮ Previous
Next ❯

Citations

May 2, 2014·BMC Biology·Catherine PfefferliChantal Wicky
Sep 3, 2013·Molecular Neurobiology·Ping FangYan-Qin Shen
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shinji MakinoMark T Keating
May 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Zhao QinPamela A Raymond
Apr 14, 2010·Zebrafish·Douglas Oppedal, Matthew I Goldsmith
Oct 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cameron WyattCatherina G Becker
Nov 17, 1999·The European Journal of Neuroscience·L W RothE Reinhard
Jan 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kenneth D PossAlex Nechiporuk
Apr 2, 2004·Biological & Pharmaceutical Bulletin·Toru MatsukawaSatoru Kato
Nov 23, 2010·Molecular Neurobiology·Andy J Fischer, Rachel Bongini
Apr 6, 2012·PloS One·Maria Laura IddaDaniela Vallone
Oct 31, 2012·The European Journal of Neuroscience·Hong-Chao PanMelitta Schachner
Nov 24, 2015·Annual Review of Vision Science·Brian A Link, Ross F Collery
Jul 24, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ching-Ling LienVaughn A Starnes
May 1, 2001·The Journal of Comparative Neurology·A J Dawson, R L Meyer
Sep 22, 2019·Development·Ines J MarquesNadia Mercader
Sep 27, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alejandro Pinzon-OlejuaClaudia A O Stuermer
Apr 24, 2013·The European Journal of Neuroscience·Yong Yu, Melitta Schachner
Nov 8, 2017·Frontiers in Integrative Neuroscience·Jacqueline ReinhardAndreas Faissner
Dec 12, 2020·Molecular Biology Reports·Sayan PaulSudhakar Sivasubramaniam
Jan 21, 2021·The European Journal of Neuroscience·Maria SavvakiDomna Karagogeos
Jun 14, 2013·The Journal of Experimental Biology·Graciela A Unguez
May 18, 1999·Molecular and Cellular Neurosciences·P BormannE Reinhard
Apr 2, 2002·Experimental Neurology·Herbert M Geller, James W Fawcett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.