PMID: 8945760Nov 8, 1996Paper

Increased expression of the alpha subunit of the ciliary neurotrophic factor (CNTF) receptor by rat racial motoneurons after neonatal axotomy and CNTF treatment

Neuroscience Letters
R M Duberley, I P Johnson

Abstract

Expression by rat motoneurons of mRNAs for the alpha subunit of the ciliary neurotrophic factor receptor (CNTFR alpha), receptor tyrosine kinase-C (trkC), calcitonin gene-related peptide (CGRP) and galanin was studied by in situ hybridisation, 6d after rat facial nerve transection on postnatal day 1. Similar numbers of motoneurons in both injured and non-injured nuclei hybridised with all probes, despite a reduction in total numbers of motoneurons ipsilaterally. When ciliary neurotrophic factor (CNTF) was applied to the proximal nerve, twice as many motoneurons in the injured nucleus hybridised with the CNTFR alpha probe ipsilaterally compared to the non-injured nucleus, while motoneuronal loss was not evident. These results indicate that survival of motoneurons after neonatal axotomy and CNTF treatment is associated with increased CNTF receptor alpha expression.

References

Jul 5, 1991·Science·S DavisG D Yancopoulos
Jun 21, 1991·Brain Research. Developmental Brain Research·K B SeroogyD E Millhorn
Oct 1, 1991·Brain Research. Molecular Brain Research·T SaikaM Tohyama
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L M KaplanW W Chin
Oct 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenB Pakkenberg
Apr 1, 1993·Current Opinion in Cell Biology·S Davis, G D Yancopoulos
Apr 30, 1993·Brain Research·M MataD J Fink
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R E ClatterbuckV E Koliatsos
May 1, 1993·Neuron·D M ValenzuelaG D Yancopoulos

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Citations

Mar 9, 2004·Brain Research. Brain Research Reviews·Linda B Moran, Manuel B Graeber
Jul 14, 2010·Brain Research Bulletin·Elizabeth J Bradbury, Lucy M Carter
Jul 20, 2006·International Anesthesiology Clinics·Elizabeth Vernon PittsRita J Balice-Gordon

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