Increased expression of the beta 1, alpha 5, and alpha v integrin adhesion receptor subunits occurs coincident with remodeling of stress-deprived rabbit anterior cruciate and medial collateral ligaments

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
S S AbiEzziV L Woods

Abstract

The biomechanical, biochemical, and morphological properties of the anterior cruciate and medial collateral ligaments are dramatically altered in response to deprivation of normal physical forces and joint motion. Integrin adhesion receptors are known to play important roles in the tissue remodeling that occurs in the course of normal wound repair. We propose that integrins play a similar role in the remodeling of the extracellular matrix in stress-deprived periarticular ligaments. This study tests the hypothesis that altered expression of integrins on ligament fibroblasts accompanies this remodeling. The left knees of 15 New Zealand White rabbits were surgically immobilized in acute flexion and the right knees served as controls (no operation). The anterior cruciate and medial collateral ligaments were harvested at 1, 3, 5, 9, or 12 weeks after immobilization. Sections from the ligaments were immunostained with monoclonal antibodies specific for the integrin subunits beta 1, alpha 5, alpha 6, and alpha v, as well as with a negative control antibody. Fibroblasts within both the stress-deprived anterior cruciate and medial collateral ligaments demonstrated markedly increased staining for the beta 1, alpha 5, and alpha v subunits...Continue Reading

References

Jan 1, 1992·Connective Tissue Research·J HarperE Harper
Jul 11, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D S GesinkV L Woods
May 1, 1992·Journal of Applied Physiology·F L Harwood, D Amiel
Jan 1, 1991·The Journal of Clinical Investigation·E Ruoslahti
Oct 1, 1990·Matrix : Collagen and Related Research·P O NewtonW H Akeson
Jun 1, 1990·The Journal of Investigative Dermatology·R A Clark
Jan 1, 1987·Annual Review of Cell Biology·C A Buck, A F Horwitz
Mar 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P J SchreckV L Woods
Apr 1, 1994·Arthritis and Rheumatism·V L WoodsM Lotz

❮ Previous
Next ❯

Citations

Apr 2, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Adam H HsiehK L Paul Sung
Mar 29, 2014·Birth Defects Research. Part C, Embryo Today : Reviews·Denitsa DochevaAttila Aszodi
May 18, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A H HsiehK L Sung
Jan 5, 2006·Canadian Journal of Physiology and Pharmacology·Madhu M BhargavaJo A Hannafin
Apr 2, 2009·The Journal of Bone and Joint Surgery. British Volume·A P RumianA E Goodship
Oct 18, 2005·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Zenya YamamotoMuneaki Abe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
D S GesinkV L Woods
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
K L SungW H Akeson
© 2021 Meta ULC. All rights reserved