Increased expression of the sodium/iodide symporter in papillary thyroid carcinomas

The Journal of Clinical Investigation
T SaitoT Onaya

Abstract

Iodide is concentrated to a much lesser extent by papillary thyroid carcinoma as compared with the normal gland. The Na+/I- symporter (NIS) is primarily responsible for the uptake of iodide into thyroid cells. Our objective was to compare NIS mRNA and protein expression in papillary carcinomas with those in specimens with normal thyroid. Northern blot analysis revealed a 2.8-fold increase in the level of NIS mRNA in specimens with papillary carcinoma versus specimens with normal thyroid. Immunoblot analysis using anti-human NIS antibody that was produced with a glutathione S-transferase fusion protein containing NIS protein (amino acids 466-522) showed the NIS protein at 77 kD. The NIS protein level was elevated in 7 of 17 cases of papillary carcinoma but was not elevated in the normal thyroid. Immunohistochemical staining revealed abundant NIS in 8 of 12 carcinomas, whereas NIS protein was barely detected in specimens with normal thyroid. Although considerable patient-to-patient variation was observed, our results indicate that NIS mRNA is elevated, and its protein tends to be more abundant, in a subset of papillary thyroid carcinomas than in normal thyroid tissue.

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References

Oct 1, 1978·The Journal of Clinical Endocrinology and Metabolism·H TakahashiC Y Lee
Feb 1, 1976·The Journal of Clinical Endocrinology and Metabolism·Y IchikawaT Muraki
Nov 1, 1978·The Journal of Clinical Endocrinology and Metabolism·J B FieldA Dekker
Feb 14, 1991·Biochemical and Biophysical Research Communications·K OhtaT Onaya
Jun 1, 1988·The Journal of Clinical Endocrinology and Metabolism·P RogerJ E Dumont
Feb 1, 1985·The Journal of Clinical Endocrinology and Metabolism·N A SamaanN G Ordonez
Jun 1, 1973·The Journal of Clinical Endocrinology and Metabolism·R D Leeper
Nov 23, 1970·JAMA : the Journal of the American Medical Association·V M VarmaJ E Copp
Oct 20, 1983·The New England Journal of Medicine·H R MaxonE L Saenger
Jul 1, 1983·The Journal of Clinical Endocrinology and Metabolism·M SchlumbergerM Tubiana
Apr 1, 1980·The Journal of Clinical Endocrinology and Metabolism·J M GoldmanJ Robbins
Oct 1, 1980·The Journal of Clinical Endocrinology and Metabolism·P CarayonM Tubiana
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·S M KaminskyN Carrasco
Jul 5, 1996·Biochemical and Biophysical Research Communications·T EndoT Onaya
Jan 1, 1996·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·D SimonH D Röher
Feb 1, 1997·Thyroid : Official Journal of the American Thyroid Association·J C MorrisJ I Mechanick
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·O LevyN Carrasco

❮ Previous
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Citations

Apr 6, 2004·Molecular and Cellular Endocrinology·Orsolya Dohán, Nancy Carrasco
Mar 9, 2000·Trends in Endocrinology and Metabolism : TEM·O DohanN Carrasco
Feb 23, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Martin SchlumbergerJean-Michel Bidart
Oct 23, 2002·Clinical Endocrinology·Christine Spitzweg, John C Morris
Mar 7, 2001·Kidney International·C SpitzwegJ C Morris
Jul 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·T KogaiG A Brent
Sep 29, 2001·Thyroid : Official Journal of the American Thyroid Association·A E HeufelderW Joba
Mar 29, 2001·Thyroid : Official Journal of the American Thyroid Association·D RussoM Derwahl
Dec 16, 1998·Thyroid : Official Journal of the American Thyroid Association·R WinzerJ Köhrle
Jul 7, 2000·Thyroid : Official Journal of the American Thyroid Association·C Schmutzler, J Köhrle
Mar 27, 2007·Thyroid : Official Journal of the American Thyroid Association·Antongiulio FaggianoMartin Schlumberger
Nov 19, 2008·Thyroid : Official Journal of the American Thyroid Association·Eleonore FröhlichRichard Wahl
May 2, 2012·Thyroid : Official Journal of the American Thyroid Association·Inga KolleckerGeorg Brabant
Aug 27, 2009·Journal of Cell Science·Vicki E SmithChristopher J McCabe
Jun 27, 2013·Future Oncology·Takahiko Kogai
Feb 4, 2014·Cancer Treatment Reviews·Eleonore Fröhlich, Richard Wahl
Mar 10, 2015·International Journal of Molecular Sciences·Justus WeberWalter Mier
Jul 4, 2012·Pharmacology & Therapeutics·Takahiko Kogai, Gregory A Brent
Aug 30, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alessandro AntonelliPaolo Miccoli
Aug 3, 2006·Surgical Oncology Clinics of North America·Ronald J Weigel, I Ross McDougall
Aug 22, 2003·Seminars in Nuclear Medicine·Zohar KeidarYodphat Krausz
Mar 23, 2005·Pathologie-biologie·E Plantin-CarrenardJ-L Beaudeux
Aug 27, 2015·Endocrine-related Cancer·Fernanda VaismanMario Vaisman
Apr 23, 2002·Clinical Endocrinology·Peter P A Smyth, Roisin M Dwyer
Aug 9, 2007·Arquivos brasileiros de endocrinologia e metabologia·Sabrina Mendes CoelhoMário Vaisman
Jan 21, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Tetsuo KondoRyohei Katoh
Apr 13, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M D RingelR M Tuttle
May 12, 2000·Thyroid : Official Journal of the American Thyroid Association·C SpitzwegJ C Morris
Apr 25, 2000·Thyroid : Official Journal of the American Thyroid Association·H J ParkI M Ahn
Feb 3, 2007·International Journal of Cancer. Journal International Du Cancer·Yun ChoiAnd Chul-Woo Kim

❮ Previous
Next ❯

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