Increased expression of the TIAR protein in the hippocampus of Alzheimer patients

Neuroreport
V H OleanaD F Swaab

Abstract

T-cell restricted intracellular antigen related protein (TIAR) is an RNA-binding protein that is supposed to be involved in the process of stress-induced apoptosis. TIAR triggers DNA fragmentation in permeabilized thymocytes and its expression diminishes in the cell nucleus and rises simultaneously in the cytoplasm during Fas-induced cell death. Using a monoclonal antibody against TIAR, we stained different areas of the hippocampus from seven controls and 14 patients with Alzheimer's disease (AD). There was a clear expression of TIAR in the hippocampus of non-demented controls. Surprisingly, a significant increase was found in the expression of TIAR in the hippocampal area in AD. The increased expression of TIAR in AD may be related to the process of neurodegeneration in the hippocampus.

References

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Feb 1, 1995·Molecular Neurobiology·C W Cotman, A J Anderson
Sep 1, 1995·Journal of Neuropathology and Experimental Neurology·A SalehiD F Swaab

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Citations

Feb 24, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·A J AndersonB J Cummings
Oct 6, 2007·The International Journal of Neuroscience·Shuqiao YaoXiaoli Qi
Jun 3, 2004·Journal of Cellular Physiology·Hongxiang HuiRiccardo Perfetti
Jan 20, 2004·Cancer Research·Charles R TessierJeff Ross
Mar 4, 2000·Journal of Neuroscience Research·K JinD A Greenberg

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