Increased expression of thyroid hormone receptor isoforms in end-stage human congestive heart failure

The Journal of Clinical Endocrinology and Metabolism
G d'AmatiF S Celi

Abstract

Thyroid hormone plays an important role on myocardial development and function. The local effects of thyroid hormone are mediated by the receptor isoforms ultimately driving the expression of cardiac-specific genes. Although overt and subclinical thyroid dysfunction causes well-known changes in the cardiovascular system, little is known about local thyroid hormone action in normal and failing human myocardium. With a newly developed multiplex competitive RT-PCR method, we evaluated the expression of thyroid hormone receptor (TR) isoforms alpha-1, alpha-2, and beta-1 in normal human hearts and in end-stage congestive heart failure. A statistically significant difference in the expression of all three TR isoforms was observed among samples from normal subjects, ischemic heart disease (IHD), and dilated cardiomyopathy (DCM). In DCM, compared with normal, the studied TR isoforms were significantly increased. In IHD, the increased expression was found significant only for alpha-1 and alpha-2 isoforms. No differences were observed between the pathologic groups. In conclusion, a coordinated increment in the expression of the TR isoforms was observed in both DCM and IHD by multiplex competitive RT-PCR. The observed changes could repres...Continue Reading

References

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Citations

Apr 1, 2014·Oxidative Medicine and Cellular Longevity·Constantinos Pantos, Iordanis Mourouzis
Feb 3, 2016·Current Heart Failure Reports·Ingrid HopperThomas G von Lueder
May 11, 2010·Cardiovascular Research·Yuan-Yuan WangToshiyuki Sasaguri
Nov 23, 2007·Biochemical Pharmacology·Pietro Amedeo ModestiAlessandra Modesti
Jul 20, 2007·Pflügers Archiv : European journal of physiology·Yoni AthéaRenée Ventura-Clapier

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