PMID: 7336125Oct 1, 1981Paper

Increased extravasation and lymphatic return rate of albumin during diuretic treatment of ascites in patients with liver cirrhosis

Scandinavian Journal of Clinical and Laboratory Investigation
J H Henriksen, P Schlichting

Abstract

During steady state the overall lymphatic return rate of albumin equals the transvascular escape rate of albumin [TERalb, i.e. the fraction of intravascular mass of albumin (IVMalb) passing to the extravascular space per unit time] provided local back-transport is negligible, as previously substantiated in patients with cirrhosis. In nine untreated patients with cirrhotic ascites, TERalb (as determined from the disappearance of intravenously injected radiodinated serum albumin) was on the average 8.5% IVMalb X h-1 (range 4.6-12.7). This value is higher than that of normals (mean 5.9% IVMalb X h-1, range 4.3-7.4, P less than 0.05, one-sided tests). During diuretic treatment TERalb increased to a mean of 13.0% IVMalb.h-1 (range 9.2-22.2), which is significantly higher compared to the untreated state (P less than 0.05) and compared to normals (P less than 0.01). In the untreated condition IVMalb was mean 1.24 mmol (range 0.96-1.64), and this value increased by 20% (P less than 0.01) to an average of 1.49 mmol (range 1.36-1.79) during diuretic treatment. The average increase in IVMalb (0.25 mmol) corresponded to 45% of the intraperitoneal mass of albumin in the untreated state (mean 0.59 mmol), indicating a net transport of albumin...Continue Reading

References

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May 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·J H HenriksenP Schlichting
Apr 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·J H HenriksenK Winkler
Oct 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation·J H HenriksenK Winkler
Oct 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·J H HenriksenK Winkler
Oct 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·J H HenriksenK Winkler
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Citations

Feb 15, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·S S NayakA R Aroor
Mar 1, 1984·Microvascular Research·J H Henriksen
Sep 17, 2004·Scandinavian Journal of Clinical and Laboratory Investigation·J H Henriksen
Sep 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H Henriksen, H Ring-Larsen
Apr 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·J H Henriksen, H Ring-Larsen
Oct 1, 1983·Scandinavian Journal of Gastroenterology·J H Henriksen
Feb 17, 2021·EJNMMI Radiopharmacy and Chemistry·Youssef ChahidHein J Verberne

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