Increased familial risk of the psychotic phenotype of Alzheimer disease

Neurology
Robert A SweetSteven T DeKosky

Abstract

Psychotic symptoms in patients with AD (AD with psychosis [AD+P]) define a phenotype characterized by more rapid cognitive and functional decline and a liability to aggressive behaviors. To determine if AD+P aggregates within families. Case-control study of AD+P frequency in 461 siblings of 371 probands diagnosed with AD. All siblings were ascertained as part of a genetic investigation and also were diagnosed with AD. Statistical analysis used Generalized Estimating Equations to adjust for clustering within families. AD+P in probands was associated with a significantly increased risk for AD+P in family members (OR, 2.41; 95% CI 1.46-4.0; p = 0.0006). The correlation among siblings for AD+P status was modest: 0.16. AD+P demonstrates familial aggregation. Further studies are required to investigate a possible genetic basis of AD+P.

Citations

Oct 12, 2005·Archives of Neurology·Nikolaos ScarmeasYaakov Stern
Jan 12, 2011·Archives of Neurology·Angela NerviRichard Mayeux
Jan 6, 2011·International Psychogeriatrics·Janardhanan C NarayanaswamyThennarasu Kandavel
Oct 19, 2011·Molecular Psychiatry·P HollingworthJ Williams
Feb 12, 2010·Brain : a Journal of Neurology·Robert A SweetUNKNOWN National Institute on Aging Late-Onset Alzheimer's Disease Family Study Group
Mar 29, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·George T Grossberg, Abhilash K Desai
Aug 12, 2006·Dementia and Geriatric Cognitive Disorders·Corinne FischerSean B Rourke
Aug 11, 2007·Dementia and Geriatric Cognitive Disorders·Antonia L PritchardCorinne L Lendon
Aug 28, 2012·Dementia and Geriatric Cognitive Disorders·Patricia Araújo PereiraDebora Marques Miranda
Apr 20, 2005·PharmacoEconomics·Daniel L Murman, Christopher C Colenda
Feb 1, 2014·Dementia and Geriatric Cognitive Disorders·Liana G ApostolovaJeffrey L Cummings
Jun 3, 2014·Current Genetic Medicine Reports·Mary Ann A DeMichele-Sweet, Robert A Sweet
Sep 26, 2013·Journal of Neural Transmission·Ke-Sheng WangChun Xu
May 16, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Jeremy KoppelUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 10, 2013·Biological Psychiatry·Patrick S MurrayRobert A Sweet
Jan 13, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Chintan ShahRobert A Sweet
Mar 15, 2012·Brain Research Bulletin·Petroula Proitsi, John F Powell
May 12, 2011·International Journal of Alzheimer's Disease·Francesco PanzaAlberto Pilotto
Jul 3, 2003·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Sarah E CookRobert A Sweet
Feb 25, 2009·International Journal of Geriatric Psychiatry·Antonia L PritchardCorinne L Lendon
May 12, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·P HollingworthJ Williams
Oct 20, 2010·International Journal of Geriatric Psychiatry·Paul HollingworthJulie Williams
Mar 23, 2011·Journal of Cellular and Molecular Medicine·Kurt A Jellinger
Apr 4, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Patricia A WilkoszRobert A Sweet
Nov 14, 2006·Neurobiology of Aging·Antonia L PritchardCorinne L Lendon
Mar 21, 2012·Neurobiology of Aging·Patrick S MurrayRobert A Sweet
Aug 6, 2010·Neurobiology of Aging·Petroula ProitsiJohn F Powell
Aug 6, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Rodney C P GoRobert A Sweet
May 26, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Patricia A WilkoszRobert A Sweet
Sep 12, 2003·Journal of Geriatric Psychiatry and Neurology·Jordi ClarimónDavid Comas
Aug 2, 2006·Journal of Geriatric Psychiatry and Neurology·Deborah Blacker, Simon Lovestone
May 13, 2003·Molecular Psychiatry·R A SweetD V Jeste
Apr 12, 2013·Journal of Neurochemistry·Peter PenzesRobert A Sweet
Aug 2, 2019·International Journal of Geriatric Psychiatry·Fabrizia D'AntonioMaddalena Boccia
Dec 18, 2019·Psychiatry and Clinical Neurosciences·Natalie SeilerBrian O'Donoghue
Aug 28, 2020·World Journal of Psychiatry·Shilpa SrinivasanArushi Kapoor
May 4, 2017·Molecular Psychiatry·M A A DeMichele-SweetR A Sweet
Oct 14, 2020·Current Neurology and Neuroscience Reports·Clive BallardRobert A Sweet
Jun 12, 2021·Molecular Psychiatry·Mary Ann A DeMichele-SweetRobert A Sweet

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