Abstract
The Fas antigen (Fas), which is a cell surface protein belonging to the tumor necrosis factor receptor family, mediates apoptosis. To assess the contribution of Fas to the pathogenesis of retrovirus-induced immunodeficiency, we examined the kinetics of Fas expression on the lymphocytes during the course of murine acquired immunodeficiency syndrome (MAIDS) induced by a defective LP-BM5 murine leukemia virus. The Fas-positive cells were increased in proportion both in alpha beta T cells and B cells with the progression of MAIDS. The appearance of Fas-positive cells in alpha beta T cells preceded those in B cells during the course of MAIDS. Among alpha beta T cells, about half of the Thy1.2+ alpha beta T cells were positive for Fas, while almost all of Thy1.2- CD4+ alpha beta T cells were of the Fas-positive phenotype. The Fas-positive cells in MAIDS mice, especially unique Thy1.2-CD4+ alpha beta T cells, were easily rendered apoptotic by stimulation via Fas, indicating that Fas expressed on the lymphocytes is functional. Furthermore, concomitant infection with Mycobacterium avium in MAIDS mice caused a marked increase in Fas-positive cells accompanied by a severely impaired T cell reactivity to polyclonal stimuli. Taken together,...Continue Reading
References
Sep 1, 1992·Journal of Virology·Y KuboS Yanagawa
Feb 1, 1992·The Journal of Experimental Medicine·H GrouxJ C Ameisen
Jul 10, 1992·Science·L MeyaardF Miedema
Sep 3, 1992·Nature·M RöckenE M Shevach
Oct 1, 1992·The Journal of Experimental Medicine·N K BandaT H Finkel
Jul 1, 1992·AIDS·H C MorseJ W Hartley
Jun 1, 1992·The Journal of Experimental Medicine·G MuralidharS L Swain
Apr 15, 1991·Annals of Internal Medicine·A S FauciG Pantaleo
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N KobayashiS Yonehara
Jul 26, 1991·Cell·N ItohS Nagata
Dec 1, 1990·European Journal of Immunology·K L HolmesK Hayakawa
Nov 1, 1990·The Journal of Experimental Medicine·L A JonesA M Kruisbeck
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S K ChattopadhyayJ W Hartley
Mar 10, 1989·Cell·V KindlerP Vassalli
May 4, 1989·Nature·G E GriffinG J Nabel
Aug 1, 1988·The Journal of Experimental Medicine·R A YetterH C Morse
May 1, 1982·Cytometry·J L DanglL A Herzenberg
Dec 1, 1993·The Journal of Experimental Medicine·M R AldersonD H Lynch
Dec 17, 1993·Cell·T SudaS Nagata
Aug 26, 1993·Nature·J OgasawaraS Nagata
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J DrappaK B Elkon
May 28, 1993·Science·M L Gougeon, L Montagnier
Sep 10, 1993·Cell·G T Williams, C A Smith
Oct 15, 1993·Cellular Immunology·D A CohenA M Kaplan
Aug 13, 1993·Cell·W HeldH R MacDonald
Jan 1, 1993·The Journal of Infectious Diseases·R S WallisJ J Ellner
Citations
Jan 1, 1996·Springer Seminars in Immunopathology·N M PonzioG J Thorbecke
Jul 2, 1999·Experimental Hematology·A R ChaudhuriJ P Maciejewski
Jan 1, 1997·Microbiology and Immunology·K HiromatsuY Yoshikai
Mar 10, 1995·Science·S Nagata, P Golstein
Feb 17, 2001·Infection and Immunity·V Nagabhushanam, C Cheers
Mar 13, 2001·Annual Review of Immunology·M K JenkinsK A Pape
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·P Scheipers, H Reiser
Sep 1, 1995·European Journal of Immunology·O KanagawaJ H Russell
Jan 10, 1998·The Journal of Pathology·D A FerenbachD J Harrison
Nov 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Masayuki UmemuraYasunobu Yoshikai
Jul 28, 1995·The Journal of Biological Chemistry·N WadaY Nakanishi
Mar 10, 1998·The Journal of Veterinary Medical Science·T MorimuraM Onuma
Aug 5, 1999·Autoimmunity·T C Martins, A P Aguas
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karsten GülowPeter H Krammer
Sep 21, 2000·American Journal of Physiology. Renal Physiology·E GulbinsF Lang
Aug 1, 1995·Journal of Virology·H YoshidaK Nomoto
Dec 1, 1996·Journal of Virology·J UsamiY Yoshikai