PMID: 9663566Jul 15, 1998Paper

Increased Fas-mediated cytotoxicity of CD4-positive T cells in patients with human T-lymphotropic virus type I-associated myelopathy

Journal of Neuroimmunology
Y NishiuraK Eguchi

Abstract

Using a 51Cr release assay, we investigated Fas-mediated cytotoxicity of peripheral blood CD4+ T cells of patients with human T-lymphotropic virus type-I (HTLV-I)-associated myelopathy (HAM) against T98G, a glioblastoma cell line which expresses Fas. Cytotoxic activity of CD4+ T cells against T98G was significantly higher in HAM patients than in controls. Moreover, when CD4+ T cells of HAM patients were preincubated with a monoclonal antibody to human Fas ligand (FasL), cytotoxic activity against T98G was significantly suppressed. These results suggest that damage to nervous tissues by the Fas/FasL system is involved in the pathogenesis of HAM.

References

Dec 1, 1995·Brain Research. Molecular Brain Research·T MatsuyamaM Sugita
Aug 1, 1996·The Tohoku Journal of Experimental Medicine·Y NishiuraS Nagataki
Dec 1, 1996·The Journal of Experimental Medicine·S D D'SouzaJ P Antel

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